TMEM100 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell of artery	9 studies	50% ± 26%	Explore
endothelial cell	7 studies	30% ± 14%	Explore
capillary endothelial cell	6 studies	58% ± 26%	Explore
vein endothelial cell	4 studies	30% ± 19%	Explore
fibroblast	3 studies	19% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMEM100 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	60%	361.19	1585 / 2642	98%	103.13	694 / 705
thymus	90%	628.91	586 / 653	64%	14.38	388 / 605
ovary	98%	2104.89	176 / 180	53%	18.76	228 / 430
lung	100%	16082.59	577 / 578	43%	6.24	498 / 1155
prostate	87%	799.84	213 / 245	51%	4.38	258 / 502
breast	99%	2303.69	455 / 459	25%	2.56	275 / 1118
stomach	93%	2269.08	334 / 359	16%	1.74	45 / 286
intestine	99%	1155.00	953 / 966	9%	0.82	45 / 527
bladder	95%	887.67	20 / 21	12%	1.19	60 / 504
adrenal gland	22%	92.77	57 / 258	84%	19.38	193 / 230
adipose	100%	2419.74	1200 / 1204	0%	0	0 / 0
esophagus	87%	741.43	1253 / 1445	5%	0.26	10 / 183
heart	88%	776.11	754 / 861	0%	0	0 / 0
uterus	59%	331.08	101 / 170	19%	4.37	87 / 459
spleen	71%	530.35	172 / 241	0%	0	0 / 0
skin	60%	347.45	1089 / 1809	10%	2.61	48 / 472
liver	45%	197.78	101 / 226	21%	3.04	84 / 406
pancreas	6%	25.10	21 / 328	53%	4.30	94 / 178
blood vessel	53%	331.42	704 / 1335	0%	0	0 / 0
muscle	50%	401.71	403 / 803	0%	0	0 / 0
kidney	10%	32.27	9 / 89	34%	4.47	304 / 901
lymph node	0%	0	0 / 0	17%	0.74	5 / 29
tonsil	0%	0	0 / 0	4%	0.23	2 / 45
peripheral blood	1%	1.91	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001525	Biological process	angiogenesis
GO_0003198	Biological process	epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0007219	Biological process	Notch signaling pathway
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0001701	Biological process	in utero embryonic development
GO_0045603	Biological process	positive regulation of endothelial cell differentiation
GO_0001570	Biological process	vasculogenesis
GO_0051930	Biological process	regulation of sensory perception of pain
GO_0030509	Biological process	BMP signaling pathway
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_0060842	Biological process	arterial endothelial cell differentiation
GO_2001214	Biological process	positive regulation of vasculogenesis
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0043204	Cellular component	perikaryon
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

Gene name	TMEM100
Protein name	Transmembrane protein 100
Synonyms
Description	FUNCTION: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. .
Accessions	ENST00000575734.5 ENST00000424486.3 Q9NV29 ENST00000571679.1 A0A0A0MTR3

TMEM100 report