Name | Number of supported studies | Average coverage | |
---|---|---|---|
CD4-positive, alpha-beta T cell | 11 studies | 22% ± 7% | |
regulatory T cell | 10 studies | 21% ± 4% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 8 studies | 25% ± 7% | |
basal cell | 7 studies | 32% ± 13% | |
epithelial cell | 6 studies | 31% ± 9% | |
CD4-positive, alpha-beta memory T cell | 5 studies | 22% ± 3% | |
CD8-positive, alpha-beta T cell | 5 studies | 21% ± 4% | |
erythroblast | 4 studies | 31% ± 8% | |
effector memory CD4-positive, alpha-beta T cell | 4 studies | 26% ± 2% | |
natural killer cell | 4 studies | 20% ± 5% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 19% ± 2% | |
plasmablast | 3 studies | 44% ± 13% | |
T cell | 3 studies | 19% ± 5% | |
ciliated cell | 3 studies | 30% ± 6% | |
effector CD4-positive, alpha-beta T cell | 3 studies | 25% ± 4% | |
glutamatergic neuron | 3 studies | 25% ± 6% | |
dendritic cell | 3 studies | 23% ± 3% | |
erythrocyte | 3 studies | 33% ± 11% | |
naive B cell | 3 studies | 19% ± 2% | |
plasmacytoid dendritic cell | 3 studies | 18% ± 3% | |
interneuron | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
liver | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 434.25 | 180 / 180 | 100% | 21.75 | 430 / 430 |
uterus | 100% | 355.00 | 170 / 170 | 100% | 22.79 | 458 / 459 |
bladder | 100% | 362.86 | 21 / 21 | 100% | 14.76 | 502 / 504 |
thymus | 100% | 556.12 | 652 / 653 | 99% | 13.50 | 601 / 605 |
intestine | 99% | 348.44 | 960 / 966 | 99% | 13.85 | 524 / 527 |
breast | 100% | 348.13 | 458 / 459 | 99% | 10.93 | 1105 / 1118 |
esophagus | 99% | 819.12 | 1431 / 1445 | 99% | 18.40 | 182 / 183 |
skin | 100% | 650.57 | 1806 / 1809 | 98% | 8.61 | 463 / 472 |
stomach | 99% | 315.88 | 355 / 359 | 99% | 12.86 | 283 / 286 |
prostate | 100% | 356.06 | 245 / 245 | 98% | 7.38 | 490 / 502 |
lung | 94% | 262.34 | 546 / 578 | 98% | 14.73 | 1129 / 1155 |
liver | 99% | 273.62 | 223 / 226 | 91% | 6.66 | 370 / 406 |
pancreas | 94% | 200.76 | 307 / 328 | 96% | 7.89 | 171 / 178 |
kidney | 98% | 318.39 | 87 / 89 | 89% | 5.97 | 800 / 901 |
brain | 94% | 488.88 | 2487 / 2642 | 92% | 5.96 | 646 / 705 |
adrenal gland | 99% | 350.10 | 255 / 258 | 84% | 9.37 | 194 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.11 | 29 / 29 |
spleen | 100% | 421.31 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 33.62 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.35 | 1 / 1 |
adipose | 99% | 299.25 | 1191 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 96% | 230.66 | 1283 / 1335 | 0% | 0 | 0 / 0 |
muscle | 91% | 170.01 | 728 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 83% | 4.86 | 66 / 80 |
heart | 79% | 134.23 | 678 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 67% | 373.77 | 627 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_0008380 | Biological process | RNA splicing |
GO_0006397 | Biological process | mRNA processing |
GO_0016607 | Cellular component | nuclear speck |
GO_0000445 | Cellular component | THO complex part of transcription export complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000346 | Cellular component | transcription export complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0003723 | Molecular function | RNA binding |
Gene name | THOC3 |
Protein name | THO complex subunit 3 THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) |
Synonyms | |
Description | FUNCTION: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. . |
Accessions | ENST00000265097.9 [Q96J01-1] D6RGZ2 ENST00000628318.2 H0YAJ0 ENST00000514250.1 ENST00000432305.6 ENST00000511062.5 Q96J01 H0YA11 H7C0C5 D6REC9 ENST00000505969.1 ENST00000513006.1 ENST00000515016.1 H0Y9T1 H0YAG7 ENST00000513482.1 [Q96J01-2] ENST00000514861.5 |