THOC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0016607Cellular componentnuclear speck
GO_0000445Cellular componentTHO complex part of transcription export complex
GO_0005654Cellular componentnucleoplasm
GO_0000346Cellular componenttranscription export complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTHOC3
Protein nameTHO complex subunit 3
THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)
Synonyms
DescriptionFUNCTION: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. .

AccessionsENST00000265097.9 [Q96J01-1]
D6RGZ2
ENST00000628318.2
H0YAJ0
ENST00000514250.1
ENST00000432305.6
ENST00000511062.5
Q96J01
H0YA11
H7C0C5
D6REC9
ENST00000505969.1
ENST00000513006.1
ENST00000515016.1
H0Y9T1
H0YAG7
ENST00000513482.1 [Q96J01-2]
ENST00000514861.5