Name | Number of supported studies | Average coverage | |
---|---|---|---|
regulatory T cell | 17 studies | 23% ± 8% | |
CD4-positive, alpha-beta T cell | 16 studies | 21% ± 5% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 14 studies | 23% ± 6% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 9 studies | 23% ± 5% | |
CD4-positive, alpha-beta memory T cell | 7 studies | 21% ± 4% | |
mucosal invariant T cell | 6 studies | 19% ± 2% | |
retinal rod cell | 5 studies | 20% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 17% ± 1% | |
retinal cone cell | 4 studies | 29% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 27% ± 8% | |
oligodendrocyte | 4 studies | 22% ± 4% | |
endothelial cell | 3 studies | 19% ± 5% | |
epithelial cell | 3 studies | 31% ± 12% | |
lymphocyte | 3 studies | 16% ± 1% | |
GABAergic neuron | 3 studies | 40% ± 9% | |
glutamatergic neuron | 3 studies | 43% ± 10% | |
dendritic cell | 3 studies | 29% ± 10% | |
effector memory CD4-positive, alpha-beta T cell | 3 studies | 28% ± 2% | |
astrocyte | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 934.05 | 226 / 226 | 100% | 9.21 | 406 / 406 |
thymus | 100% | 1598.42 | 653 / 653 | 100% | 14.09 | 605 / 605 |
breast | 100% | 1122.29 | 459 / 459 | 100% | 15.41 | 1116 / 1118 |
prostate | 100% | 1249.30 | 245 / 245 | 100% | 10.22 | 501 / 502 |
ovary | 100% | 1081.89 | 180 / 180 | 100% | 10.45 | 429 / 430 |
pancreas | 100% | 922.49 | 327 / 328 | 100% | 9.03 | 178 / 178 |
kidney | 100% | 1771.15 | 89 / 89 | 100% | 10.46 | 898 / 901 |
adrenal gland | 100% | 1922.88 | 258 / 258 | 100% | 13.17 | 229 / 230 |
skin | 100% | 778.30 | 1803 / 1809 | 100% | 24.08 | 471 / 472 |
intestine | 100% | 924.86 | 966 / 966 | 99% | 9.14 | 524 / 527 |
stomach | 100% | 747.58 | 359 / 359 | 99% | 10.03 | 282 / 286 |
esophagus | 100% | 744.75 | 1440 / 1445 | 99% | 12.11 | 181 / 183 |
bladder | 100% | 1191.33 | 21 / 21 | 97% | 9.70 | 490 / 504 |
uterus | 100% | 1101.72 | 170 / 170 | 97% | 9.54 | 445 / 459 |
lung | 98% | 809.38 | 567 / 578 | 98% | 11.60 | 1132 / 1155 |
brain | 100% | 1079.73 | 2638 / 2642 | 94% | 8.93 | 664 / 705 |
adipose | 100% | 1008.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.29 | 29 / 29 |
muscle | 100% | 1149.89 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1217.68 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.22 | 1 / 1 |
blood vessel | 99% | 573.26 | 1324 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.90 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 98% | 9.48 | 78 / 80 |
heart | 97% | 1086.06 | 839 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 84% | 511.17 | 782 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_1902108 | Biological process | regulation of mitochondrial membrane permeability involved in apoptotic process |
GO_0006631 | Biological process | fatty acid metabolic process |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005758 | Cellular component | mitochondrial intermembrane space |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005886 | Cellular component | plasma membrane |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0052816 | Molecular function | long-chain fatty acyl-CoA hydrolase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | THEM4 |
Protein name | Thioesterase superfamily member 4 Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) |
Synonyms | CTMP |
Description | FUNCTION: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. . |
Accessions | F6XC58 Q5T1C6 ENST00000489410.1 E9PLJ7 ENST00000471464.5 ENST00000368814.8 |