THEM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1902108Biological processregulation of mitochondrial membrane permeability involved in apoptotic process
GO_0006631Biological processfatty acid metabolic process
GO_0032587Cellular componentruffle membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005886Cellular componentplasma membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHEM4
Protein nameThioesterase superfamily member 4
Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)
SynonymsCTMP
DescriptionFUNCTION: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. .

AccessionsF6XC58
Q5T1C6
ENST00000489410.1
E9PLJ7
ENST00000471464.5
ENST00000368814.8