TENM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0007218Biological processneuropeptide signaling pathway
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0006955Biological processimmune response
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0048666Biological processneuron development
GO_0006359Biological processregulation of transcription by RNA polymerase III
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0007399Biological processnervous system development
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0016363Cellular componentnuclear matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008201Molecular functionheparin binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0050839Molecular functioncell adhesion molecule binding
GO_0046982Molecular functionprotein heterodimerization activity

IV. Literature review

[source]
Gene nameTENM1
Protein nameTeneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)]
Teneurin transmembrane protein 1
SynonymsODZ1
TNM1
DescriptionFUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). .; FUNCTION: [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). .; FUNCTION: [Ten-1 intracellular domain]: Induces gene transcription activation. .

AccessionsQ9UKZ4
ENST00000422452.3
A0A8Z5AZJ6
ENST00000371130.7 [Q9UKZ4-1]