TEAD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEAD2 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0006366Biological processtranscription by RNA polymerase II
GO_0048568Biological processembryonic organ development
GO_0048368Biological processlateral mesoderm development
GO_0035329Biological processhippo signaling
GO_2000736Biological processregulation of stem cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048339Biological processparaxial mesoderm development
GO_0001570Biological processvasculogenesis
GO_0065003Biological processprotein-containing complex assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001843Biological processneural tube closure
GO_0006355Biological processregulation of DNA-templated transcription
GO_0003143Biological processembryonic heart tube morphogenesis
GO_0030903Biological processnotochord development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140552Cellular componentTEAD-YAP complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTEAD2
Protein nameTEA domain transcription factor 2
Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)
SynonymsTEF4
DescriptionFUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. .

AccessionsENST00000598810.5 [Q15562-4]
ENST00000601519.5 [Q15562-2]
ENST00000311227.6 [Q15562-1]
M0R290
Q15562
M0R1A5
ENST00000598823.5
ENST00000377214.8 [Q15562-2]
ENST00000596757.1
ENST00000539846.5 [Q15562-3]
ENST00000593945.6 [Q15562-4]