SYTL2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	18 studies	26% ± 17%	Explore
mast cell	17 studies	32% ± 16%	Explore
natural killer cell	17 studies	25% ± 13%	Explore
smooth muscle cell	15 studies	32% ± 22%	Explore
mucosal invariant T cell	13 studies	26% ± 8%	Explore
ciliated cell	12 studies	28% ± 11%	Explore
CD8-positive, alpha-beta T cell	12 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	19% ± 4%	Explore
T cell	9 studies	24% ± 10%	Explore
goblet cell	9 studies	47% ± 23%	Explore
gamma-delta T cell	9 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	29% ± 17%	Explore
oligodendrocyte	8 studies	26% ± 8%	Explore
glutamatergic neuron	7 studies	47% ± 25%	Explore
epithelial cell	6 studies	24% ± 11%	Explore
respiratory goblet cell	6 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	27% ± 4%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
myofibroblast cell	5 studies	26% ± 4%	Explore
mature NK T cell	5 studies	19% ± 1%	Explore
endothelial cell	4 studies	23% ± 6%	Explore
basal cell	4 studies	41% ± 27%	Explore
fibroblast	4 studies	47% ± 30%	Explore
innate lymphoid cell	4 studies	34% ± 27%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 16%	Explore
astrocyte	4 studies	26% ± 11%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 7%	Explore
renal principal cell	4 studies	22% ± 5%	Explore
club cell	3 studies	32% ± 15%	Explore
secretory cell	3 studies	32% ± 7%	Explore
retinal ganglion cell	3 studies	35% ± 10%	Explore
CD4-positive helper T cell	3 studies	47% ± 29%	Explore
abnormal cell	3 studies	19% ± 5%	Explore
muscle cell	3 studies	32% ± 2%	Explore
GABAergic neuron	3 studies	40% ± 7%	Explore
lymphocyte	3 studies	35% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	40% ± 18%	Explore
lung	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	3626.13	358 / 359	92%	16.89	264 / 286
kidney	100%	3384.62	89 / 89	90%	29.57	813 / 901
prostate	100%	2888.94	245 / 245	90%	14.17	451 / 502
breast	97%	2892.62	446 / 459	91%	39.82	1017 / 1118
intestine	89%	3446.18	861 / 966	92%	17.74	484 / 527
brain	89%	3263.23	2343 / 2642	87%	12.05	615 / 705
bladder	100%	3739.24	21 / 21	76%	11.61	381 / 504
lung	99%	2558.95	574 / 578	73%	10.85	840 / 1155
skin	88%	1729.19	1599 / 1809	69%	11.06	325 / 472
uterus	96%	1709.49	164 / 170	42%	5.03	194 / 459
esophagus	64%	774.48	921 / 1445	58%	10.86	106 / 183
thymus	81%	1010.71	532 / 653	33%	2.44	199 / 605
adrenal gland	85%	1130.59	220 / 258	26%	5.42	60 / 230
pancreas	10%	94.28	34 / 328	91%	18.35	162 / 178
ureter	0%	0	0 / 0	100%	14.90	1 / 1
blood vessel	97%	5651.28	1299 / 1335	0%	0	0 / 0
adipose	97%	2985.64	1162 / 1204	0%	0	0 / 0
spleen	91%	1051.34	219 / 241	0%	0	0 / 0
ovary	56%	686.73	100 / 180	21%	1.33	90 / 430
heart	49%	574.03	424 / 861	0%	0	0 / 0
liver	39%	386.90	89 / 226	8%	0.59	34 / 406
peripheral blood	27%	382.95	252 / 929	0%	0	0 / 0
muscle	27%	269.08	217 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	24%	1.69	7 / 29
tonsil	0%	0	0 / 0	16%	2.83	7 / 45
eye	0%	0	0 / 0	6%	0.32	5 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016192	Biological process	vesicle-mediated transport
GO_0006904	Biological process	vesicle docking involved in exocytosis
GO_0006886	Biological process	intracellular protein transport
GO_0006887	Biological process	exocytosis
GO_0070382	Cellular component	exocytic vesicle
GO_0042470	Cellular component	melanosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0042043	Molecular function	neurexin family protein binding
GO_0019902	Molecular function	phosphatase binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding

IV. Literature review

[source]

Gene name	SYTL2
Protein name	Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) Synaptotagmin like 2
Synonyms	SLP2 SGA72M SLP2A KIAA1597
Description	FUNCTION: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. .
Accessions	ENST00000530351.5 E9PK22 E9PS29 A0A8J9FM55 E9PS39 E9PQL8 ENST00000529534.5 ENST00000634661.1 ENST00000528231.5 [Q9HCH5-1] ENST00000526999.5 E9PRW5 ENST00000359152.10 ENST00000527794.5 Q9HCH5 ENST00000389959.8 A0A0U1RR07 ENST00000525702.5 [Q9HCH5-2] ENST00000532995.5 ENST00000533057.6 E9PIB5 ENST00000529581.5 [Q9HCH5-2] A0A0U1RRJ3 E9PPL3 ENST00000389958.7 [Q9HCH5-9] ENST00000533892.5 [Q9HCH5-4] ENST00000532221.5 ENST00000533577.1 ENST00000524911.5 ENST00000316356.8 [Q9HCH5-13] A0A0U1RQH1 ENST00000527523.5 [Q9HCH5-14] A0A1Y8EH08 ENST00000389960.8 [Q9HCH5-6] ENST00000524452.5 [Q9HCH5-6]

SYTL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review