SUN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070197Biological processmeiotic attachment of telomere to nuclear envelope
GO_0007283Biological processspermatogenesis
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0051642Biological processcentrosome localization
GO_0090292Biological processnuclear matrix anchoring at nuclear membrane
GO_0009612Biological processresponse to mechanical stimulus
GO_0001503Biological processossification
GO_0021817Biological processnucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000781Cellular componentchromosome, telomeric region
GO_0031965Cellular componentnuclear membrane
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005521Molecular functionlamin binding
GO_0005515Molecular functionprotein binding
GO_0140444Molecular functioncytoskeleton-nuclear membrane anchor activity

IV. Literature review

[source]
Gene nameSUN1
Protein nameSUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)
Sad1 and UNC84 domain containing 1
SUN domain-containing protein 1
SynonymsKIAA0810
UNC84A
DescriptionFUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton . The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links . .

AccessionsA0A146IHP0
ENST00000425407.6 [O94901-5]
ENST00000429178.5
ENST00000440380.5
H0Y742
ENST00000452783.6
ENST00000424128.5
ENST00000421580.5
ENST00000433212.5
H0Y6N5
E9PHI4
C9JR15
ENST00000419312.5
C9JS54
ENST00000457378.6 [O94901-7]
C9JJU6
ENST00000435699.5
ENST00000439679.5
C9JK55
C9K051
H7C2K3
ENST00000450881.5
ENST00000457861.1
ENST00000403868.5 [O94901-2]
H7C3X3
A0A8I5G938
ENST00000401592.6 [O94901-8]
ENST00000405266.5
O94901
ENST00000457598.5
H7C019
ENST00000389574.7 [O94901-5]