STXBP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017157Biological processregulation of exocytosis
GO_0006887Biological processexocytosis
GO_0010807Biological processregulation of synaptic vesicle priming
GO_0006893Biological processGolgi to plasma membrane transport
GO_0015031Biological processprotein transport
GO_0045921Biological processpositive regulation of exocytosis
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0098674Cellular componentextrinsic component of neuronal dense core vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0005737Cellular componentcytoplasm
GO_0005892Cellular componentacetylcholine-gated channel complex
GO_0031201Cellular componentSNARE complex
GO_0045159Molecular functionmyosin II binding
GO_0005096Molecular functionGTPase activator activity
GO_0017075Molecular functionsyntaxin-1 binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameSTXBP5
Protein nameSyntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1)
Syntaxin binding protein 5
STXBP5 protein
Syntaxin binding protein 5 (Tomosyn)
SynonymsLLGL3
hCG_16767
DescriptionFUNCTION: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). .

AccessionsF6VFW0
H0Y332
Q3B794
ENST00000367475.7
ENST00000706849.1 [Q5T5C0-2]
ENST00000367481.7 [Q5T5C0-2]
Q5T5C0
A0A9L9PY07
ENST00000706854.1
ENST00000321680.11 [Q5T5C0-1]
ENST00000706851.1
ENST00000706850.1 [Q5T5C0-2]
A0A9L9PXY2
ENST00000367480.7 [Q5T5C0-3]
ENST00000546097.5
Q14DD4