SPTBN4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	61% ± 26%	Explore
GABAergic neuron	10 studies	52% ± 29%	Explore
astrocyte	8 studies	29% ± 12%	Explore
amacrine cell	7 studies	37% ± 15%	Explore
oligodendrocyte precursor cell	7 studies	26% ± 10%	Explore
interneuron	6 studies	54% ± 28%	Explore
retinal ganglion cell	6 studies	54% ± 23%	Explore
neuron	5 studies	32% ± 9%	Explore
endothelial cell	4 studies	40% ± 21%	Explore
granule cell	4 studies	45% ± 18%	Explore
retina horizontal cell	4 studies	37% ± 9%	Explore
GABAergic interneuron	3 studies	52% ± 8%	Explore
OFF-bipolar cell	3 studies	39% ± 24%	Explore
retinal cone cell	3 studies	18% ± 3%	Explore
retinal rod cell	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	43% ± 24%	Explore
eye	3 studies	25% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	7642.40	2629 / 2642	98%	10.67	694 / 705
prostate	76%	615.11	186 / 245	91%	2.44	457 / 502
ovary	97%	1214.72	174 / 180	35%	0.88	152 / 430
adrenal gland	31%	263.12	80 / 258	87%	14.88	199 / 230
uterus	86%	742.61	146 / 170	22%	0.70	101 / 459
esophagus	52%	405.00	750 / 1445	11%	0.34	21 / 183
breast	15%	91.19	68 / 459	47%	1.43	521 / 1118
bladder	52%	349.38	11 / 21	9%	0.24	45 / 504
heart	58%	392.26	501 / 861	0%	0	0 / 0
thymus	15%	88.34	96 / 653	40%	0.78	244 / 605
intestine	45%	324.39	434 / 966	9%	0.29	45 / 527
muscle	50%	325.11	400 / 803	0%	0	0 / 0
stomach	28%	217.57	102 / 359	16%	0.42	46 / 286
pancreas	3%	21.61	11 / 328	39%	2.32	69 / 178
kidney	6%	30.27	5 / 89	23%	0.72	204 / 901
adipose	25%	162.57	298 / 1204	0%	0	0 / 0
skin	4%	22.86	72 / 1809	11%	0.21	53 / 472
lung	0%	0	0 / 578	14%	0.34	164 / 1155
eye	0%	0	0 / 0	14%	0.51	11 / 80
liver	1%	8.55	3 / 226	11%	0.18	45 / 406
blood vessel	9%	57.29	122 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.25	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0007628	Biological process	adult walking behavior
GO_0072659	Biological process	protein localization to plasma membrane
GO_0033135	Biological process	regulation of peptidyl-serine phosphorylation
GO_0002028	Biological process	regulation of sodium ion transport
GO_0045162	Biological process	clustering of voltage-gated sodium channels
GO_0010459	Biological process	negative regulation of heart rate
GO_0051693	Biological process	actin filament capping
GO_0050905	Biological process	neuromuscular process
GO_0007528	Biological process	neuromuscular junction development
GO_0065003	Biological process	protein-containing complex assembly
GO_0007409	Biological process	axonogenesis
GO_0030036	Biological process	actin cytoskeleton organization
GO_0016192	Biological process	vesicle-mediated transport
GO_0021952	Biological process	central nervous system projection neuron axonogenesis
GO_0009566	Biological process	fertilization
GO_0061337	Biological process	cardiac conduction
GO_0019226	Biological process	transmission of nerve impulse
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070852	Cellular component	cell body fiber
GO_0043203	Cellular component	axon hillock
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0043025	Cellular component	neuronal cell body
GO_0043194	Cellular component	axon initial segment
GO_0005884	Cellular component	actin filament
GO_0016363	Cellular component	nuclear matrix
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0033270	Cellular component	paranode region of axon
GO_0016605	Cellular component	PML body
GO_0044224	Cellular component	juxtaparanode region of axon
GO_0005737	Cellular component	cytoplasm
GO_0033268	Cellular component	node of Ranvier
GO_0042995	Cellular component	cell projection
GO_0030054	Cellular component	cell junction
GO_0014704	Cellular component	intercalated disc
GO_0008091	Cellular component	spectrin
GO_0106006	Molecular function	cytoskeletal protein-membrane anchor activity
GO_0005543	Molecular function	phospholipid binding
GO_0030507	Molecular function	spectrin binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0019902	Molecular function	phosphatase binding
GO_0030506	Molecular function	ankyrin binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

Gene name	SPTBN4
Protein name	Spectrin beta chain Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3) Spectrin beta, non-erythrocytic 4
Synonyms	SPTBN3 KIAA1642
Description
Accessions	ENST00000595535.5 ENST00000352632.7 [Q9H254-1] ENST00000598249.6 [Q9H254-1] M0QZQ3 M0R1V6 ENST00000597389.5 ENST00000392023.1 [Q9H254-5] Q9H254

SPTBN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review