SPON2 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	38 studies	54% ± 18%	Explore
fibroblast	34 studies	34% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	75% ± 12%	Explore
pericyte	14 studies	36% ± 11%	Explore
mature NK T cell	14 studies	42% ± 18%	Explore
connective tissue cell	11 studies	38% ± 18%	Explore
CD8-positive, alpha-beta T cell	10 studies	29% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	33% ± 16%	Explore
gamma-delta T cell	10 studies	28% ± 8%	Explore
myofibroblast cell	9 studies	28% ± 9%	Explore
plasmacytoid dendritic cell	6 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 8%	Explore
smooth muscle cell	4 studies	20% ± 5%	Explore
adventitial cell	4 studies	38% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	24% ± 3%	Explore
T cell	3 studies	19% ± 3%	Explore
lymphocyte	3 studies	23% ± 2%	Explore
mucosal invariant T cell	3 studies	19% ± 3%	Explore
ciliated cell	3 studies	24% ± 6%	Explore
innate lymphoid cell	3 studies	28% ± 13%	Explore
double negative thymocyte	3 studies	21% ± 5%	Explore

Name	Number of supported studies	Average coverage
intestine	5 studies	28% ± 14%	Explore
peripheral blood	5 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	11026.16	245 / 245	99%	835.38	498 / 502
liver	100%	4503.65	226 / 226	96%	95.79	389 / 406
intestine	100%	5290.00	964 / 966	87%	41.63	461 / 527
stomach	98%	3326.44	352 / 359	89%	41.58	254 / 286
breast	99%	5005.94	453 / 459	75%	30.66	838 / 1118
esophagus	99%	3778.10	1427 / 1445	74%	28.21	136 / 183
kidney	94%	3322.88	84 / 89	76%	76.65	683 / 901
skin	97%	6200.24	1763 / 1809	67%	59.50	314 / 472
bladder	100%	6601.14	21 / 21	63%	30.76	320 / 504
uterus	100%	13553.09	170 / 170	63%	33.19	290 / 459
lung	100%	6171.30	576 / 578	60%	24.45	696 / 1155
pancreas	55%	818.83	182 / 328	92%	84.48	164 / 178
ovary	89%	3166.96	160 / 180	46%	12.80	198 / 430
adrenal gland	97%	3473.43	250 / 258	10%	3.52	23 / 230
spleen	100%	3003.53	241 / 241	0%	0	0 / 0
adipose	98%	5312.68	1175 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	94%	124.77	75 / 80
heart	82%	1737.70	705 / 861	0%	0	0 / 0
thymus	71%	1494.41	462 / 653	6%	1.09	34 / 605
peripheral blood	71%	3699.53	663 / 929	0%	0	0 / 0
brain	33%	811.03	874 / 2642	10%	3.23	73 / 705
tonsil	0%	0	0 / 0	40%	15.02	18 / 45
blood vessel	34%	702.64	460 / 1335	0%	0	0 / 0
muscle	32%	485.75	256 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	21%	5.37	6 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0002448	Biological process	mast cell mediated immunity
GO_0051607	Biological process	defense response to virus
GO_0008228	Biological process	opsonization
GO_0050832	Biological process	defense response to fungus
GO_0043152	Biological process	induction of bacterial agglutination
GO_0007155	Biological process	cell adhesion
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0045087	Biological process	innate immune response
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0070062	Cellular component	extracellular exosome
GO_0031012	Cellular component	extracellular matrix
GO_0003823	Molecular function	antigen binding
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

Gene name	SPON2
Protein name	Spondin 2 Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin)
Synonyms	DIL1 UNQ435/PRO866
Description	FUNCTION: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). .
Accessions	ENST00000431380.5 ENST00000290902.10 D6RA41 D6RIH5 D6REX2 ENST00000515004.5 A0A1Y8ELY7 ENST00000511672.5 ENST00000503765.5 ENST00000511679.5 D6RB12 ENST00000502483.5 ENST00000509233.5 D6RBY3 ENST00000617421.4 D6RFY9 ENST00000514490.5 Q9BUD6

SPON2 report