Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 37% ± 18% | |
fibroblast | 17 studies | 22% ± 8% | |
endothelial cell | 14 studies | 31% ± 15% | |
oligodendrocyte | 13 studies | 38% ± 13% | |
glutamatergic neuron | 12 studies | 50% ± 24% | |
oligodendrocyte precursor cell | 12 studies | 38% ± 16% | |
microglial cell | 12 studies | 39% ± 11% | |
GABAergic neuron | 11 studies | 49% ± 23% | |
macrophage | 11 studies | 33% ± 14% | |
neuron | 9 studies | 40% ± 18% | |
smooth muscle cell | 8 studies | 21% ± 4% | |
pericyte | 7 studies | 26% ± 12% | |
epithelial cell | 7 studies | 40% ± 16% | |
interneuron | 6 studies | 56% ± 24% | |
myofibroblast cell | 6 studies | 23% ± 7% | |
retina horizontal cell | 6 studies | 28% ± 8% | |
adipocyte | 6 studies | 25% ± 5% | |
type I pneumocyte | 6 studies | 25% ± 9% | |
basal cell | 5 studies | 26% ± 14% | |
amacrine cell | 5 studies | 29% ± 5% | |
connective tissue cell | 5 studies | 23% ± 4% | |
granule cell | 4 studies | 28% ± 8% | |
retinal ganglion cell | 4 studies | 30% ± 4% | |
retinal pigment epithelial cell | 4 studies | 36% ± 21% | |
cardiac muscle cell | 4 studies | 21% ± 2% | |
myeloid cell | 4 studies | 27% ± 4% | |
Mueller cell | 4 studies | 28% ± 7% | |
retinal cone cell | 4 studies | 27% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 22% ± 1% | |
goblet cell | 4 studies | 25% ± 12% | |
GABAergic interneuron | 3 studies | 47% ± 3% | |
ciliated cell | 3 studies | 33% ± 11% | |
GABAergic amacrine cell | 3 studies | 28% ± 4% | |
glycinergic amacrine cell | 3 studies | 29% ± 2% | |
retinal rod cell | 3 studies | 24% ± 4% | |
ependymal cell | 3 studies | 56% ± 12% | |
club cell | 3 studies | 23% ± 7% | |
alveolar macrophage | 3 studies | 27% ± 9% | |
transit amplifying cell | 3 studies | 32% ± 20% | |
mast cell | 3 studies | 20% ± 2% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 25% ± 5% | |
kidney loop of Henle epithelial cell | 3 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5322.71 | 1445 / 1445 | 100% | 71.37 | 183 / 183 |
ovary | 100% | 9906.60 | 180 / 180 | 100% | 86.12 | 430 / 430 |
brain | 100% | 7709.76 | 2642 / 2642 | 100% | 92.62 | 703 / 705 |
lung | 100% | 4442.47 | 576 / 578 | 100% | 61.47 | 1155 / 1155 |
prostate | 100% | 6870.49 | 245 / 245 | 100% | 74.48 | 500 / 502 |
breast | 100% | 5924.60 | 459 / 459 | 99% | 104.66 | 1112 / 1118 |
kidney | 100% | 5842.74 | 89 / 89 | 99% | 75.96 | 892 / 901 |
intestine | 100% | 5671.65 | 966 / 966 | 99% | 50.99 | 521 / 527 |
bladder | 100% | 5610.00 | 21 / 21 | 99% | 56.47 | 497 / 504 |
stomach | 100% | 3867.51 | 359 / 359 | 99% | 52.02 | 282 / 286 |
thymus | 100% | 7274.66 | 653 / 653 | 98% | 84.93 | 595 / 605 |
adrenal gland | 100% | 4450.28 | 258 / 258 | 98% | 53.52 | 226 / 230 |
uterus | 100% | 9847.75 | 170 / 170 | 98% | 74.49 | 450 / 459 |
pancreas | 99% | 2737.17 | 325 / 328 | 99% | 65.21 | 176 / 178 |
skin | 100% | 5415.36 | 1808 / 1809 | 95% | 48.93 | 447 / 472 |
liver | 87% | 1429.05 | 197 / 226 | 72% | 23.98 | 293 / 406 |
adipose | 100% | 4963.13 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7871.33 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3038.44 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 54.25 | 1 / 1 |
tonsil | 0% | 0 | 0 / 0 | 98% | 61.15 | 44 / 45 |
heart | 92% | 3054.18 | 795 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 85% | 30.21 | 68 / 80 |
lymph node | 0% | 0 | 0 / 0 | 69% | 19.32 | 20 / 29 |
peripheral blood | 26% | 479.70 | 242 / 929 | 0% | 0 | 0 / 0 |
muscle | 16% | 207.75 | 125 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006325 | Biological process | chromatin organization |
GO_0051321 | Biological process | meiotic cell cycle |
GO_0007276 | Biological process | gamete generation |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0009303 | Biological process | rRNA transcription |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005819 | Cellular component | spindle |
GO_0005634 | Cellular component | nucleus |
GO_0035064 | Molecular function | methylated histone binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SPIN1 |
Protein name | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) |
Synonyms | OCR SPIN |
Description | FUNCTION: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway . Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes . May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. . |
Accessions | Q9Y657 ENST00000375859.4 |