SP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032869Biological processcellular response to insulin stimulus
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0045766Biological processpositive regulation of angiogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0071391Biological processcellular response to estrogen stimulus
GO_0033194Biological processresponse to hydroperoxide
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_1904568Biological processcellular response to wortmannin
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1904828Biological processpositive regulation of hydrogen sulfide biosynthetic process
GO_0048511Biological processrhythmic process
GO_0034224Biological processcellular response to zinc ion starvation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0060090Molecular functionmolecular adaptor activity
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSP1
Protein nameSp1 transcription factor, isoform CRA_a (cDNA, FLJ92269)
Transcription factor Sp1
Pregnancy-specific protein
Sp1 transcription factor
Alternative protein SP1
SynonymsTSFP1
hCG_1787889
DescriptionFUNCTION: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 . Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). .

AccessionsL8E7F4
ENST00000426431.2 [P08047-2]
B2R4Y6
ENST00000548560.1
ENST00000551969.5
P08047
H3BUU5
Q15403
H3BVI2
ENST00000327443.9 [P08047-1]