SNAP25 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	13 studies	42% ± 16%	Explore
glutamatergic neuron	11 studies	82% ± 21%	Explore
astrocyte	11 studies	32% ± 9%	Explore
GABAergic neuron	10 studies	66% ± 28%	Explore
microglial cell	10 studies	27% ± 11%	Explore
neuron	9 studies	52% ± 21%	Explore
retinal rod cell	9 studies	63% ± 17%	Explore
amacrine cell	8 studies	73% ± 18%	Explore
retinal cone cell	8 studies	73% ± 15%	Explore
retinal ganglion cell	7 studies	83% ± 21%	Explore
oligodendrocyte	7 studies	32% ± 13%	Explore
interneuron	6 studies	61% ± 30%	Explore
endothelial cell	5 studies	47% ± 14%	Explore
retinal bipolar neuron	5 studies	79% ± 15%	Explore
OFF-bipolar cell	5 studies	75% ± 19%	Explore
ON-bipolar cell	5 studies	81% ± 14%	Explore
retina horizontal cell	5 studies	43% ± 16%	Explore
granule cell	4 studies	73% ± 24%	Explore
GABAergic amacrine cell	4 studies	75% ± 26%	Explore
glycinergic amacrine cell	4 studies	66% ± 21%	Explore
pancreatic A cell	3 studies	51% ± 16%	Explore
type B pancreatic cell	3 studies	56% ± 11%	Explore
GABAergic interneuron	3 studies	66% ± 16%	Explore
Mueller cell	3 studies	33% ± 4%	Explore
rod bipolar cell	3 studies	97% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	46% ± 26%	Explore
eye	9 studies	58% ± 17%	Explore
pancreas	3 studies	43% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	87750.24	2493 / 2642	99%	305.50	698 / 705
adrenal gland	4%	328.71	10 / 258	94%	189.07	216 / 230
pancreas	0%	12.09	1 / 328	72%	18.16	128 / 178
kidney	0%	0	0 / 89	72%	8.33	648 / 901
ovary	7%	396.83	13 / 180	47%	4.90	202 / 430
thymus	0%	0	0 / 653	48%	3.14	289 / 605
liver	0%	0	0 / 226	38%	8.33	154 / 406
uterus	1%	55.51	2 / 170	26%	5.79	119 / 459
prostate	1%	57.43	3 / 245	25%	1.42	126 / 502
skin	0%	0	0 / 1809	23%	2.31	107 / 472
eye	0%	0	0 / 0	23%	8.11	18 / 80
tonsil	0%	0	0 / 0	20%	2.71	9 / 45
lung	0%	0	0 / 578	20%	2.55	226 / 1155
stomach	0%	0	0 / 359	14%	3.04	39 / 286
breast	0%	0	0 / 459	12%	5.16	138 / 1118
lymph node	0%	0	0 / 0	10%	0.40	3 / 29
esophagus	0%	4.31	1 / 1445	9%	1.99	17 / 183
intestine	0%	10.95	2 / 966	9%	1.98	45 / 527
bladder	0%	0	0 / 21	9%	2.33	43 / 504
blood vessel	0%	6.11	2 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050796	Biological process	regulation of insulin secretion
GO_0007616	Biological process	long-term memory
GO_0008306	Biological process	associative learning
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0060291	Biological process	long-term synaptic potentiation
GO_0098967	Biological process	exocytic insertion of neurotransmitter receptor to postsynaptic membrane
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0035493	Biological process	SNARE complex assembly
GO_0016081	Biological process	synaptic vesicle docking
GO_0007409	Biological process	axonogenesis
GO_0016197	Biological process	endosomal transport
GO_0099525	Biological process	presynaptic dense core vesicle exocytosis
GO_0001504	Biological process	neurotransmitter uptake
GO_0006887	Biological process	exocytosis
GO_0007268	Biological process	chemical synaptic transmission
GO_0051963	Biological process	regulation of synapse assembly
GO_0016082	Biological process	synaptic vesicle priming
GO_0099590	Biological process	neurotransmitter receptor internalization
GO_0010975	Biological process	regulation of neuron projection development
GO_0031629	Biological process	synaptic vesicle fusion to presynaptic active zone membrane
GO_0007626	Biological process	locomotory behavior
GO_0098978	Cellular component	glutamatergic synapse
GO_0070032	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO_0005856	Cellular component	cytoskeleton
GO_0031982	Cellular component	vesicle
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0001917	Cellular component	photoreceptor inner segment
GO_0098794	Cellular component	postsynapse
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0042734	Cellular component	presynaptic membrane
GO_0070033	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO_0005802	Cellular component	trans-Golgi network
GO_0097470	Cellular component	ribbon synapse
GO_0030175	Cellular component	filopodium
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0008021	Cellular component	synaptic vesicle
GO_0070821	Cellular component	tertiary granule membrane
GO_0030426	Cellular component	growth cone
GO_0031083	Cellular component	BLOC-1 complex
GO_0044295	Cellular component	axonal growth cone
GO_0005737	Cellular component	cytoplasm
GO_0098888	Cellular component	extrinsic component of presynaptic membrane
GO_0070044	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO_0005768	Cellular component	endosome
GO_0030027	Cellular component	lamellipodium
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0031201	Cellular component	SNARE complex
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0019904	Molecular function	protein domain specific binding
GO_0008289	Molecular function	lipid binding
GO_0017022	Molecular function	myosin binding
GO_0017075	Molecular function	syntaxin-1 binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005484	Molecular function	SNAP receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SNAP25
Protein name	Synaptosomal-associated protein 25 (SNAP-25) Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)
Synonyms	SNAP
Description	FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. . FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. .
Accessions	ENST00000254976.7 [P60880-1] ENST00000691161.1 [P60880-1] ENST00000687785.1 [P60880-1] ENST00000430336.1 ENST00000691665.1 [P60880-1] ENST00000693325.1 [P60880-1] ENST00000690812.1 [P60880-1] ENST00000691353.1 [P60880-1] P60880 ENST00000689757.1 [P60880-1] A0A0A0MSS0 ENST00000304886.6 [P60880-2] ENST00000689858.1 [P60880-1] ENST00000685131.1 [P60880-1] ENST00000692411.1 [P60880-1] ENST00000706269.1 [P60880-2]

SNAP25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review