SLX4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLX4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLX4 at tissue level.

III. Associated gene sets

GO_0010792Biological processDNA double-strand break processing involved in repair via single-strand annealing
GO_0090656Biological processt-circle formation
GO_0006281Biological processDNA repair
GO_0006289Biological processnucleotide-excision repair
GO_0006260Biological processDNA replication
GO_1904357Biological processnegative regulation of telomere maintenance via telomere lengthening
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0032206Biological processpositive regulation of telomere maintenance
GO_0061820Biological processtelomeric D-loop disassembly
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0072429Biological processresponse to intra-S DNA damage checkpoint signaling
GO_1904431Biological processpositive regulation of t-circle formation
GO_0033557Cellular componentSlx1-Slx4 complex
GO_0005654Cellular componentnucleoplasm
GO_0070522Cellular componentERCC4-ERCC1 complex
GO_0005829Cellular componentcytosol
GO_0030054Cellular componentcell junction
GO_0048476Cellular componentHolliday junction resolvase complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0003677Molecular functionDNA binding
GO_0008047Molecular functionenzyme activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLX4
Protein nameStructure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
SynonymsBTBD12
KIAA1784
KIAA1987
DescriptionFUNCTION: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. .

AccessionsQ8IY92
ENST00000294008.4 [Q8IY92-1]