SLC25A11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035435Biological processphosphate ion transmembrane transport
GO_0015729Biological processoxaloacetate transport
GO_0071422Biological processsuccinate transmembrane transport
GO_1902356Biological processoxaloacetate(2-) transmembrane transport
GO_0008272Biological processsulfate transport
GO_0015709Biological processthiosulfate transport
GO_0015742Biological processalpha-ketoglutarate transport
GO_0006094Biological processgluconeogenesis
GO_1902358Biological processsulfate transmembrane transport
GO_0071423Biological processmalate transmembrane transport
GO_0006869Biological processlipid transport
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005634Cellular componentnucleus
GO_0015117Molecular functionthiosulfate transmembrane transporter activity
GO_0015116Molecular functionsulfate transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015131Molecular functionoxaloacetate transmembrane transporter activity
GO_0003723Molecular functionRNA binding
GO_0015141Molecular functionsuccinate transmembrane transporter activity
GO_0015367Molecular functionoxoglutarate:malate antiporter activity
GO_0005515Molecular functionprotein binding
GO_0015140Molecular functionmalate transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A11
Protein nameMitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11)
Mitochondrial 2-oxoglutarate/malate carrier protein (Solute carrier family 25 member 11)
SynonymshCG_32694
SLC20A4
DescriptionFUNCTION: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae . Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). .

AccessionsENST00000576951.1
ENST00000225665.12 [Q02978-1]
ENST00000544061.6 [Q02978-2]
I3L1P8
Q02978
Q6IBH0