SLC1A2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	20 studies	69% ± 26%	Explore
oligodendrocyte precursor cell	15 studies	61% ± 19%	Explore
glutamatergic neuron	9 studies	39% ± 21%	Explore
GABAergic neuron	8 studies	45% ± 15%	Explore
retinal rod cell	7 studies	38% ± 19%	Explore
retinal cone cell	7 studies	30% ± 11%	Explore
endothelial cell	6 studies	31% ± 14%	Explore
retinal bipolar neuron	5 studies	27% ± 11%	Explore
interneuron	5 studies	39% ± 18%	Explore
neuron	4 studies	32% ± 9%	Explore
GABAergic interneuron	3 studies	28% ± 9%	Explore
granule cell	3 studies	34% ± 20%	Explore
OFF-bipolar cell	3 studies	63% ± 5%	Explore
rod bipolar cell	3 studies	30% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	32% ± 14%	Explore
eye	5 studies	33% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	108593.88	2599 / 2642	99%	141.36	701 / 705
liver	37%	1848.34	83 / 226	62%	7.80	250 / 406
breast	0%	0	0 / 459	58%	3.45	654 / 1118
pancreas	42%	1754.11	137 / 328	13%	0.30	24 / 178
adrenal gland	5%	502.07	14 / 258	44%	1.80	101 / 230
prostate	0%	0	0 / 245	7%	0.13	35 / 502
lymph node	0%	0	0 / 0	7%	0.17	2 / 29
uterus	0%	0	0 / 170	6%	0.14	29 / 459
lung	0%	0	0 / 578	6%	0.15	69 / 1155
ovary	0%	0	0 / 180	5%	0.12	22 / 430
stomach	1%	31.34	3 / 359	4%	0.12	11 / 286
tonsil	0%	0	0 / 0	4%	0.08	2 / 45
esophagus	0%	4.47	2 / 1445	4%	0.08	7 / 183
intestine	0%	10.85	1 / 966	3%	0.09	18 / 527
kidney	0%	0	0 / 89	3%	0.11	31 / 901
eye	0%	0	0 / 0	3%	0.13	2 / 80
thymus	0%	0	0 / 653	2%	0.04	12 / 605
skin	0%	3.45	2 / 1809	2%	0.06	8 / 472
bladder	0%	0	0 / 21	2%	0.10	9 / 504
muscle	0%	3.87	1 / 803	0%	0	0 / 0
heart	0%	8.64	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0070779	Biological process	D-aspartate import across plasma membrane
GO_0070778	Biological process	L-aspartate transmembrane transport
GO_0043200	Biological process	response to amino acid
GO_0046326	Biological process	positive regulation of glucose import
GO_1903712	Biological process	cysteine transmembrane transport
GO_0098656	Biological process	monoatomic anion transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0070633	Biological process	transepithelial transport
GO_0015813	Biological process	L-glutamate transmembrane transport
GO_0006811	Biological process	monoatomic ion transport
GO_0098712	Biological process	L-glutamate import across plasma membrane
GO_0035264	Biological process	multicellular organism growth
GO_0070207	Biological process	protein homotrimerization
GO_0006750	Biological process	glutathione biosynthetic process
GO_0098810	Biological process	neurotransmitter reuptake
GO_0071314	Biological process	cellular response to cocaine
GO_0007268	Biological process	chemical synaptic transmission
GO_0006836	Biological process	neurotransmitter transport
GO_0030534	Biological process	adult behavior
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0140009	Biological process	L-aspartate import across plasma membrane
GO_0009611	Biological process	response to wounding
GO_0007632	Biological process	visual behavior
GO_0021537	Biological process	telencephalon development
GO_0098796	Cellular component	membrane protein complex
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0009986	Cellular component	cell surface
GO_0030673	Cellular component	axolemma
GO_0097449	Cellular component	astrocyte projection
GO_0044297	Cellular component	cell body
GO_0044306	Cellular component	neuron projection terminus
GO_0031982	Cellular component	vesicle
GO_0015501	Molecular function	glutamate:sodium symporter activity
GO_0008509	Molecular function	monoatomic anion transmembrane transporter activity
GO_0015175	Molecular function	neutral L-amino acid transmembrane transporter activity
GO_0033229	Molecular function	cysteine transmembrane transporter activity
GO_0005313	Molecular function	L-glutamate transmembrane transporter activity
GO_0046872	Molecular function	metal ion binding
GO_0005314	Molecular function	high-affinity L-glutamate transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SLC1A2
Protein name	Amino acid transporter Solute carrier family 1 member 2 Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Synonyms	EAAT2 hCG_26509 GLT1
Description	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion . Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport . Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). .
Accessions	ENST00000531628.2 ENST00000647372.1 ENST00000647104.1 [P43004-2] ENST00000464522.2 P43004 H0YEB1 A0A2R8Y6J5 ENST00000643401.1 A0A2R8Y642 A0A2R8Y860 A0A2R8Y5Y1 A0A2R8Y4D1 ENST00000646080.1 ENST00000642578.1 ENST00000642171.1 A0A2R8YH93 A0A2R8YD46 A0A163QEF0 ENST00000643134.1 ENST00000646099.1 ENST00000606205.6 ENST00000278379.9 [P43004-1] ENST00000643000.1 [P43004-2] ENST00000449068.2 ENST00000642769.1 C9J9N5 A2A2U1 ENST00000643305.1 [P43004-3] H0YEK4 A0A2R8Y740 A0A2R8YHI4 ENST00000643522.1 A0A2U3U0E3 ENST00000644868.1 ENST00000645303.1 A0A2R8YCL7 A0A2R8Y6B8 A0A2R8YG01 A0A2R8Y4W1 A0A2R8Y4N0 ENST00000646167.1 A0A2U3TZS7 A0A2R8Y862 A0A2R8YFE3 ENST00000644299.1 [P43004-2] ENST00000644351.1 ENST00000395753.6 [P43004-2] ENST00000647076.1 ENST00000644050.1 [P43004-2] ENST00000643454.1 ENST00000644779.1 ENST00000395750.6 ENST00000645194.1 [P43004-2] ENST00000646847.1 ENST00000645634.1 [P43004-2] ENST00000644459.1

SLC1A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review