SIX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000177Biological processregulation of neural precursor cell proliferation
GO_0003404Biological processoptic vesicle morphogenesis
GO_0007601Biological processvisual perception
GO_1990086Biological processlens fiber cell apoptotic process
GO_0021846Biological processcell proliferation in forebrain
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021978Biological processtelencephalon regionalization
GO_0021798Biological processforebrain dorsal/ventral pattern formation
GO_1901987Biological processregulation of cell cycle phase transition
GO_0001654Biological processeye development
GO_1902692Biological processregulation of neuroblast proliferation
GO_0002070Biological processepithelial cell maturation
GO_0009946Biological processproximal/distal axis specification
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0061074Biological processregulation of neural retina development
GO_1902742Biological processapoptotic process involved in development
GO_0002088Biological processlens development in camera-type eye
GO_0007420Biological processbrain development
GO_0021983Biological processpituitary gland development
GO_0070306Biological processlens fiber cell differentiation
GO_0014016Biological processneuroblast differentiation
GO_0021537Biological processtelencephalon development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_0097402Biological processneuroblast migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIX3
Protein nameHomeobox protein SIX3
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)
SIX3 protein
Sine oculis homeobox-like protein 3
SIX homeobox 3
Synonyms
DescriptionFUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. .

AccessionsENST00000260653.5
A0A1Y0ZVZ1
O95343
A0A127AXF1
A0A127AXB2
A0A1Y0ZN85
A0PJI2
A0A0D3RS46