SGIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	23 studies	38% ± 21%	Explore
astrocyte	19 studies	53% ± 22%	Explore
oligodendrocyte	15 studies	49% ± 15%	Explore
oligodendrocyte precursor cell	14 studies	63% ± 18%	Explore
fibroblast	14 studies	29% ± 8%	Explore
glutamatergic neuron	12 studies	66% ± 22%	Explore
GABAergic neuron	11 studies	64% ± 22%	Explore
endothelial cell	8 studies	40% ± 17%	Explore
retinal cone cell	8 studies	71% ± 19%	Explore
retinal rod cell	8 studies	67% ± 24%	Explore
neuron	7 studies	48% ± 18%	Explore
endothelial cell of lymphatic vessel	7 studies	37% ± 15%	Explore
smooth muscle cell	7 studies	27% ± 8%	Explore
amacrine cell	6 studies	50% ± 20%	Explore
interneuron	6 studies	75% ± 14%	Explore
retinal ganglion cell	6 studies	47% ± 22%	Explore
retina horizontal cell	6 studies	45% ± 21%	Explore
Mueller cell	6 studies	52% ± 22%	Explore
retinal bipolar neuron	5 studies	34% ± 12%	Explore
microglial cell	5 studies	42% ± 19%	Explore
granule cell	4 studies	55% ± 14%	Explore
OFF-bipolar cell	4 studies	40% ± 22%	Explore
ON-bipolar cell	4 studies	36% ± 18%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	47% ± 6%	Explore
GABAergic interneuron	3 studies	74% ± 0%	Explore
GABAergic amacrine cell	3 studies	68% ± 15%	Explore
glycinergic amacrine cell	3 studies	57% ± 10%	Explore
rod bipolar cell	3 studies	56% ± 21%	Explore
ependymal cell	3 studies	52% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	54% ± 21%	Explore
eye	9 studies	48% ± 23%	Explore
kidney	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3431.27	2639 / 2642	99%	7.45	695 / 705
kidney	99%	1492.25	88 / 89	53%	2.31	482 / 901
thymus	99%	1998.20	647 / 653	50%	2.66	303 / 605
lung	98%	1852.59	569 / 578	48%	1.06	558 / 1155
breast	76%	533.24	348 / 459	69%	1.93	766 / 1118
prostate	94%	1366.36	231 / 245	47%	0.97	237 / 502
esophagus	70%	918.65	1006 / 1445	56%	1.24	102 / 183
uterus	92%	1478.51	157 / 170	30%	0.74	138 / 459
stomach	65%	485.33	233 / 359	50%	1.21	142 / 286
blood vessel	100%	4274.51	1334 / 1335	0%	0	0 / 0
intestine	60%	470.06	577 / 966	37%	0.78	193 / 527
adipose	86%	1159.82	1035 / 1204	0%	0	0 / 0
adrenal gland	13%	88.97	34 / 258	65%	7.13	150 / 230
pancreas	1%	4.67	3 / 328	75%	2.04	134 / 178
heart	74%	666.81	638 / 861	0%	0	0 / 0
bladder	48%	275.43	10 / 21	26%	0.57	133 / 504
skin	42%	475.88	766 / 1809	11%	0.25	51 / 472
ovary	34%	237.34	61 / 180	6%	0.10	25 / 430
muscle	25%	151.21	201 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	11%	0.21	5 / 45
liver	2%	12.06	5 / 226	9%	0.15	36 / 406
eye	0%	0	0 / 0	3%	0.16	2 / 80
peripheral blood	0%	0.44	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	SGIP1
Protein name	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) SH3GL interacting endocytic adaptor 1
Synonyms
Description	FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. . FUNCTION: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. .
Accessions	A0A804HKQ5 A0A804HJA8 A0A804HJS7 ENST00000683311.1 ENST00000683581.1 ENST00000684539.1 [Q9BQI5-4] ENST00000684083.1 ENST00000682419.1 A0A804HIL9 A0A804HJI3 ENST00000683207.1 A0A804HIU6 A0A804HI01 ENST00000684168.1 A0A804HIL8 ENST00000683257.1 [Q9BQI5-4] ENST00000371037.9 [Q9BQI5-1] ENST00000682416.1 A0A804HK43 A0A804HHZ7 A0A804HKA0 ENST00000682270.1 A0A804HIA5 F6R8P8 ENST00000682476.1 ENST00000682707.1 ENST00000237247.10 [Q9BQI5-3] A0A804HI53 ENST00000487507.1 ENST00000435165.3 A0A804HL75 ENST00000682816.1 ENST00000683604.1 ENST00000684664.1 [Q9BQI5-5] ENST00000683499.1 A0A804HHV6 ENST00000682054.1 ENST00000682762.1 ENST00000480548.6 ENST00000684750.1 ENST00000424320.6 A0A804HJJ5 ENST00000371039.5 [Q9BQI5-5] A0A804HKB1 ENST00000682938.1 ENST00000684651.1 A0A804HIX4 A0A804HHX3 A0A804HJX5 ENST00000683291.1 ENST00000684178.1 ENST00000682150.1 ENST00000682981.1 ENST00000682293.1 ENST00000682519.1 A0A804HJ90 ENST00000682901.1 Q9BQI5 ENST00000681971.1 ENST00000683067.1 A0A804HIP4 ENST00000684751.1 A0A804HJG4

GO_0097009	Biological process	energy homeostasis
GO_0048260	Biological process	positive regulation of receptor-mediated endocytosis
GO_0072583	Biological process	clathrin-dependent endocytosis
GO_2000253	Biological process	positive regulation of feeding behavior
GO_0002021	Biological process	response to dietary excess
GO_0030122	Cellular component	AP-2 adaptor complex
GO_0005905	Cellular component	clathrin-coated pit
GO_0005829	Cellular component	cytosol
GO_0030136	Cellular component	clathrin-coated vesicle
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding
GO_0008017	Molecular function	microtubule binding
GO_0005543	Molecular function	phospholipid binding
GO_0017124	Molecular function	SH3 domain binding

SGIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review