SESN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042149Biological processcellular response to glucose starvation
GO_1990253Biological processcellular response to leucine starvation
GO_1901031Biological processregulation of response to reactive oxygen species
GO_0032868Biological processresponse to insulin
GO_0038203Biological processTORC2 signaling
GO_0016239Biological processpositive regulation of macroautophagy
GO_0034198Biological processcellular response to amino acid starvation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0042593Biological processglucose homeostasis
GO_0071233Biological processcellular response to L-leucine
GO_0031932Cellular componentTORC2 complex
GO_0061700Cellular componentGATOR2 complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070728Molecular functionL-leucine binding
GO_0016684Molecular functionoxidoreductase activity, acting on peroxide as acceptor
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSESN3
Protein nameSestrin-3 (EC 1.11.1.-)
Sestrin 3
SynonymsSEST3
DescriptionFUNCTION: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway . May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). .

AccessionsENST00000536441.7 [P58005-1]
ENST00000634898.1
P58005
ENST00000278499.6 [P58005-4]
ENST00000542176.1
ENST00000416495.6 [P58005-3]
F5H1K7
A0A0U1RR17