Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 19 studies | 20% ± 5% | |
| astrocyte | 16 studies | 35% ± 13% | |
| regulatory T cell | 15 studies | 25% ± 9% | |
| fibroblast | 13 studies | 21% ± 4% | |
| memory B cell | 12 studies | 23% ± 6% | |
| macrophage | 11 studies | 27% ± 8% | |
| endothelial cell | 11 studies | 34% ± 11% | |
| glutamatergic neuron | 11 studies | 43% ± 25% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 10 studies | 24% ± 8% | |
| microglial cell | 10 studies | 28% ± 8% | |
| GABAergic neuron | 8 studies | 42% ± 16% | |
| oligodendrocyte precursor cell | 8 studies | 21% ± 4% | |
| endothelial cell of lymphatic vessel | 8 studies | 27% ± 6% | |
| naive B cell | 7 studies | 27% ± 5% | |
| interneuron | 7 studies | 37% ± 17% | |
| basal cell | 7 studies | 28% ± 11% | |
| CD4-positive, alpha-beta T cell | 6 studies | 22% ± 5% | |
| retinal ganglion cell | 6 studies | 36% ± 17% | |
| neuron | 5 studies | 35% ± 14% | |
| epithelial cell | 5 studies | 37% ± 20% | |
| Mueller cell | 5 studies | 25% ± 5% | |
| T follicular helper cell | 5 studies | 21% ± 3% | |
| retinal bipolar neuron | 4 studies | 20% ± 6% | |
| retinal pigment epithelial cell | 4 studies | 43% ± 14% | |
| erythrocyte | 4 studies | 29% ± 17% | |
| T cell | 4 studies | 18% ± 1% | |
| oligodendrocyte | 4 studies | 20% ± 5% | |
| pericyte | 3 studies | 32% ± 12% | |
| GABAergic interneuron | 3 studies | 31% ± 4% | |
| granule cell | 3 studies | 20% ± 4% | |
| OFF-bipolar cell | 3 studies | 44% ± 11% | |
| rod bipolar cell | 3 studies | 31% ± 9% | |
| lymphocyte | 3 studies | 19% ± 3% | |
| smooth muscle cell | 3 studies | 25% ± 9% | |
| dendritic cell | 3 studies | 25% ± 5% | |
| neural progenitor cell | 3 studies | 31% ± 1% | |
| connective tissue cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 6942.39 | 2641 / 2642 | 100% | 58.41 | 703 / 705 |
| thymus | 100% | 5394.63 | 653 / 653 | 95% | 29.55 | 572 / 605 |
| prostate | 100% | 4000.36 | 245 / 245 | 93% | 28.64 | 469 / 502 |
| lung | 100% | 3979.77 | 577 / 578 | 85% | 41.54 | 979 / 1155 |
| adrenal gland | 97% | 3838.80 | 250 / 258 | 84% | 69.46 | 194 / 230 |
| esophagus | 99% | 2827.51 | 1432 / 1445 | 80% | 39.08 | 147 / 183 |
| breast | 99% | 3780.77 | 454 / 459 | 80% | 30.79 | 895 / 1118 |
| ovary | 100% | 6604.47 | 180 / 180 | 77% | 15.55 | 331 / 430 |
| kidney | 88% | 2175.13 | 78 / 89 | 85% | 19.92 | 765 / 901 |
| skin | 93% | 3439.59 | 1685 / 1809 | 79% | 26.62 | 374 / 472 |
| uterus | 99% | 4178.30 | 168 / 170 | 70% | 20.31 | 323 / 459 |
| bladder | 95% | 3294.52 | 20 / 21 | 59% | 14.95 | 295 / 504 |
| intestine | 88% | 2678.81 | 854 / 966 | 55% | 9.74 | 289 / 527 |
| stomach | 68% | 1346.65 | 243 / 359 | 58% | 12.00 | 167 / 286 |
| pancreas | 35% | 495.39 | 116 / 328 | 85% | 17.84 | 151 / 178 |
| spleen | 100% | 4395.90 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5925.82 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 97% | 3206.02 | 1173 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 18.78 | 40 / 45 |
| peripheral blood | 82% | 1987.40 | 766 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 16.54 | 21 / 29 |
| muscle | 62% | 1247.46 | 501 / 803 | 0% | 0 | 0 / 0 |
| heart | 52% | 1071.42 | 450 / 861 | 0% | 0 | 0 / 0 |
| liver | 21% | 283.64 | 48 / 226 | 22% | 3.98 | 90 / 406 |
| eye | 0% | 0 | 0 / 0 | 31% | 3.99 | 25 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051896 | Biological process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0042149 | Biological process | cellular response to glucose starvation |
| GO_1990253 | Biological process | cellular response to leucine starvation |
| GO_1901031 | Biological process | regulation of response to reactive oxygen species |
| GO_0032868 | Biological process | response to insulin |
| GO_0038203 | Biological process | TORC2 signaling |
| GO_0016239 | Biological process | positive regulation of macroautophagy |
| GO_0034198 | Biological process | cellular response to amino acid starvation |
| GO_1904262 | Biological process | negative regulation of TORC1 signaling |
| GO_0046626 | Biological process | regulation of insulin receptor signaling pathway |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0071233 | Biological process | cellular response to L-leucine |
| GO_0031932 | Cellular component | TORC2 complex |
| GO_0061700 | Cellular component | GATOR2 complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0070728 | Molecular function | L-leucine binding |
| GO_0016684 | Molecular function | oxidoreductase activity, acting on peroxide as acceptor |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SESN3 |
| Protein name | Sestrin-3 (EC 1.11.1.-) Sestrin 3 |
| Synonyms | SEST3 |
| Description | FUNCTION: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway . May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). . |
| Accessions | ENST00000536441.7 [P58005-1] ENST00000634898.1 P58005 ENST00000278499.6 [P58005-4] ENST00000542176.1 ENST00000416495.6 [P58005-3] F5H1K7 A0A0U1RR17 |