SEPHS2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	9 studies	23% ± 8%	Explore
regulatory T cell	9 studies	18% ± 3%	Explore
pericyte	8 studies	20% ± 3%	Explore
natural killer cell	6 studies	18% ± 2%	Explore
epithelial cell	6 studies	33% ± 16%	Explore
B cell	5 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	5 studies	17% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 2%	Explore
conventional dendritic cell	4 studies	27% ± 10%	Explore
enterocyte	4 studies	27% ± 7%	Explore
basal cell	4 studies	26% ± 6%	Explore
abnormal cell	4 studies	18% ± 3%	Explore
gamma-delta T cell	4 studies	19% ± 2%	Explore
secretory cell	3 studies	20% ± 2%	Explore
pancreatic A cell	3 studies	31% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	21% ± 2%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
classical monocyte	3 studies	24% ± 6%	Explore
mature NK T cell	3 studies	17% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 5%	Explore
smooth muscle cell	3 studies	21% ± 2%	Explore
germinal center B cell	3 studies	21% ± 2%	Explore
exhausted T cell	3 studies	17% ± 2%	Explore
glutamatergic neuron	3 studies	27% ± 5%	Explore
dendritic cell	3 studies	32% ± 9%	Explore
pancreatic ductal cell	3 studies	44% ± 21%	Explore
endothelial cell of vascular tree	3 studies	19% ± 2%	Explore
brush cell	3 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	20% ± 3%	Explore
memory B cell	3 studies	16% ± 0%	Explore
naive B cell	3 studies	17% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	17% ± 1%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
intestine	5 studies	20% ± 7%	Explore
pancreas	3 studies	34% ± 15%	Explore
peripheral blood	3 studies	22% ± 6%	Explore
lung	3 studies	22% ± 1%	Explore
liver	3 studies	24% ± 6%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	21005.28	226 / 226	100%	589.68	406 / 406
stomach	100%	3606.28	359 / 359	100%	218.51	286 / 286
thymus	100%	2679.74	653 / 653	100%	108.99	603 / 605
kidney	100%	8760.60	89 / 89	100%	212.11	897 / 901
lung	99%	2618.00	575 / 578	100%	154.08	1155 / 1155
esophagus	100%	2463.66	1444 / 1445	99%	149.16	182 / 183
breast	100%	2875.26	459 / 459	99%	246.84	1111 / 1118
skin	100%	2783.27	1809 / 1809	99%	184.54	468 / 472
pancreas	100%	2049.28	327 / 328	99%	144.93	177 / 178
intestine	100%	4659.62	965 / 966	99%	190.13	522 / 527
uterus	99%	1935.75	169 / 170	99%	123.70	456 / 459
prostate	100%	2868.60	245 / 245	99%	139.31	495 / 502
bladder	100%	2346.81	21 / 21	98%	142.63	496 / 504
brain	99%	2039.61	2604 / 2642	98%	70.36	694 / 705
ovary	96%	1198.27	173 / 180	98%	89.30	421 / 430
adrenal gland	100%	3544.20	258 / 258	89%	79.02	204 / 230
adipose	100%	2783.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	225.33	29 / 29
muscle	100%	2806.83	803 / 803	0%	0	0 / 0
spleen	100%	3257.93	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	94.93	45 / 45
ureter	0%	0	0 / 0	100%	54.31	1 / 1
blood vessel	100%	1935.90	1329 / 1335	0%	0	0 / 0
peripheral blood	98%	4300.03	911 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	159.61	77 / 80
heart	95%	1776.02	816 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0