Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasma cell | 19 studies | 38% ± 11% | |
endothelial cell | 14 studies | 23% ± 8% | |
macrophage | 12 studies | 25% ± 9% | |
microglial cell | 9 studies | 28% ± 12% | |
oligodendrocyte | 9 studies | 27% ± 10% | |
fibroblast | 8 studies | 18% ± 4% | |
classical monocyte | 7 studies | 21% ± 7% | |
plasmablast | 7 studies | 28% ± 17% | |
IgA plasma cell | 7 studies | 28% ± 9% | |
IgG plasma cell | 7 studies | 29% ± 5% | |
epithelial cell | 6 studies | 31% ± 9% | |
hepatocyte | 5 studies | 33% ± 14% | |
monocyte | 5 studies | 21% ± 2% | |
goblet cell | 5 studies | 25% ± 14% | |
alveolar macrophage | 5 studies | 24% ± 9% | |
neuron | 4 studies | 26% ± 12% | |
myeloid cell | 4 studies | 25% ± 5% | |
dendritic cell | 4 studies | 27% ± 14% | |
GABAergic neuron | 4 studies | 40% ± 15% | |
astrocyte | 4 studies | 31% ± 8% | |
glutamatergic neuron | 4 studies | 49% ± 19% | |
oligodendrocyte precursor cell | 4 studies | 31% ± 10% | |
pericyte | 4 studies | 19% ± 3% | |
endothelial cell of lymphatic vessel | 3 studies | 18% ± 3% | |
ionocyte | 3 studies | 41% ± 4% | |
non-classical monocyte | 3 studies | 26% ± 11% | |
hematopoietic precursor cell | 3 studies | 17% ± 2% | |
ciliated cell | 3 studies | 21% ± 4% | |
lymphocyte | 3 studies | 18% ± 1% | |
acinar cell | 3 studies | 54% ± 25% | |
interneuron | 3 studies | 42% ± 20% | |
plasmacytoid dendritic cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 6842.79 | 578 / 578 | 100% | 50.79 | 1155 / 1155 |
esophagus | 100% | 5334.99 | 1444 / 1445 | 100% | 48.58 | 183 / 183 |
breast | 100% | 7173.37 | 459 / 459 | 100% | 71.98 | 1114 / 1118 |
prostate | 100% | 5330.87 | 244 / 245 | 100% | 103.85 | 502 / 502 |
pancreas | 100% | 47663.14 | 328 / 328 | 99% | 50.34 | 177 / 178 |
thymus | 100% | 6796.60 | 653 / 653 | 99% | 44.08 | 597 / 605 |
stomach | 100% | 5979.84 | 359 / 359 | 98% | 43.91 | 281 / 286 |
intestine | 100% | 7461.50 | 966 / 966 | 98% | 38.03 | 517 / 527 |
liver | 100% | 8984.21 | 226 / 226 | 98% | 43.69 | 398 / 406 |
brain | 98% | 3887.76 | 2597 / 2642 | 100% | 42.26 | 703 / 705 |
kidney | 100% | 4451.34 | 89 / 89 | 98% | 51.47 | 882 / 901 |
uterus | 100% | 6325.39 | 170 / 170 | 98% | 29.29 | 449 / 459 |
bladder | 100% | 7239.38 | 21 / 21 | 98% | 32.06 | 493 / 504 |
skin | 100% | 7425.67 | 1805 / 1809 | 96% | 51.91 | 455 / 472 |
adrenal gland | 100% | 5448.37 | 258 / 258 | 95% | 31.63 | 219 / 230 |
ovary | 100% | 4618.96 | 180 / 180 | 94% | 22.36 | 405 / 430 |
adipose | 100% | 8139.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9949.47 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 28.56 | 29 / 29 |
spleen | 100% | 6621.81 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.23 | 1 / 1 |
muscle | 100% | 4957.97 | 799 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 33.60 | 44 / 45 |
heart | 95% | 4009.59 | 817 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 80% | 23.15 | 64 / 80 |
peripheral blood | 78% | 4568.53 | 728 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030970 | Biological process | retrograde protein transport, ER to cytosol |
GO_0007219 | Biological process | Notch signaling pathway |
GO_0050821 | Biological process | protein stabilization |
GO_0006641 | Biological process | triglyceride metabolic process |
GO_0036503 | Biological process | ERAD pathway |
GO_0009306 | Biological process | protein secretion |
GO_0000839 | Cellular component | Hrd1p ubiquitin ligase ERAD-L complex |
GO_0036513 | Cellular component | Derlin-1 retrotranslocation complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0000836 | Cellular component | Hrd1p ubiquitin ligase complex |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005515 | Molecular function | protein binding |
Gene name | SEL1L |
Protein name | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Alternative protein SEL1L Sel-1-like protein Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L protein |
Synonyms | TSA305 UNQ128/PRO1063 |
Description | FUNCTION: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. . |
Accessions | Q3ZCU6 ENST00000555824.5 [Q9UBV2-2] Q9UBV2 L8E9A3 G3V3B3 ENST00000557372.1 ENST00000336735.9 [Q9UBV2-1] Q12916 |