SEL1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0007219Biological processNotch signaling pathway
GO_0050821Biological processprotein stabilization
GO_0006641Biological processtriglyceride metabolic process
GO_0036503Biological processERAD pathway
GO_0009306Biological processprotein secretion
GO_0000839Cellular componentHrd1p ubiquitin ligase ERAD-L complex
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0000836Cellular componentHrd1p ubiquitin ligase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEL1L
Protein nameSEL1L adaptor subunit of ERAD E3 ubiquitin ligase
Alternative protein SEL1L
Sel-1-like protein
Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)
SEL1L protein
SynonymsTSA305
UNQ128/PRO1063
DescriptionFUNCTION: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. .

AccessionsQ3ZCU6
ENST00000555824.5 [Q9UBV2-2]
Q9UBV2
L8E9A3
G3V3B3
ENST00000557372.1
ENST00000336735.9 [Q9UBV2-1]
Q12916