SASH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0000209Biological processprotein polyubiquitination
GO_0045766Biological processpositive regulation of angiogenesis
GO_0031666Biological processpositive regulation of lipopolysaccharide-mediated signaling pathway
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_1900044Biological processregulation of protein K63-linked ubiquitination
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_1902498Biological processregulation of protein autoubiquitination
GO_0010632Biological processregulation of epithelial cell migration
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0060090Molecular functionmolecular adaptor activity
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSASH1
Protein nameSASH1 protein
SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)
Alternative protein SASH1
SAM and SH3 domain containing 1
SynonymsPEPE1
KIAA0790
DescriptionFUNCTION: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation . Regulates TRAF6 and MAP3K7 ubiquitination . Involved in the regulation of cell mobility . Regulates lipolysaccharide (LPS)-induced endothelial cell migration . Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis . .

AccessionsENST00000636279.1
ENST00000637469.1
Q6P4R9
ENST00000367467.8
L8EAS6
O94885
A0A1B0GVF9
ENST00000637729.1
A0A1B0GVI0
A0A1B0GWB9