SACM1L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	15 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	19% ± 3%	Explore
endothelial cell	7 studies	25% ± 7%	Explore
microglial cell	6 studies	26% ± 7%	Explore
oligodendrocyte	6 studies	22% ± 6%	Explore
macrophage	6 studies	23% ± 7%	Explore
mature NK T cell	5 studies	18% ± 2%	Explore
epithelial cell	5 studies	29% ± 7%	Explore
astrocyte	5 studies	28% ± 8%	Explore
T cell	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
neuron	4 studies	22% ± 8%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
lymphocyte	4 studies	32% ± 14%	Explore
GABAergic neuron	4 studies	41% ± 15%	Explore
glutamatergic neuron	4 studies	51% ± 19%	Explore
interneuron	4 studies	35% ± 22%	Explore
CD8-positive, alpha-beta T cell	4 studies	16% ± 1%	Explore
ciliated cell	3 studies	22% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore
innate lymphoid cell	3 studies	19% ± 3%	Explore
type II pneumocyte	3 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 6%	Explore
dendritic cell	3 studies	21% ± 3%	Explore
endothelial cell of lymphatic vessel	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	39% ± 14%	Explore
liver	3 studies	18% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2624.24	1445 / 1445	100%	19.39	183 / 183
lung	100%	3554.15	578 / 578	100%	19.83	1155 / 1155
breast	100%	3030.78	459 / 459	100%	26.57	1116 / 1118
brain	100%	2668.28	2637 / 2642	100%	23.47	705 / 705
bladder	100%	2970.52	21 / 21	100%	18.93	503 / 504
prostate	100%	2934.22	245 / 245	100%	27.42	501 / 502
ovary	100%	2430.19	180 / 180	100%	16.01	429 / 430
thymus	100%	4437.74	653 / 653	100%	30.09	603 / 605
stomach	100%	2724.23	359 / 359	100%	20.04	285 / 286
intestine	100%	3095.48	966 / 966	99%	20.11	524 / 527
kidney	100%	2576.71	89 / 89	99%	22.94	895 / 901
pancreas	100%	1764.18	327 / 328	99%	20.35	177 / 178
uterus	100%	3233.14	170 / 170	99%	16.69	455 / 459
adrenal gland	100%	3406.24	258 / 258	99%	27.49	227 / 230
liver	100%	1712.46	226 / 226	97%	11.19	392 / 406
skin	100%	2756.58	1809 / 1809	96%	25.33	454 / 472
blood vessel	100%	2988.40	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	17.62	29 / 29
spleen	100%	3572.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.25	45 / 45
ureter	0%	0	0 / 0	100%	8.03	1 / 1
adipose	100%	3024.13	1203 / 1204	0%	0	0 / 0
heart	98%	1617.86	846 / 861	0%	0	0 / 0
muscle	98%	1135.35	787 / 803	0%	0	0 / 0
peripheral blood	88%	1822.26	813 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	13.05	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046856	Biological process	phosphatidylinositol dephosphorylation
GO_0006661	Biological process	phosphatidylinositol biosynthetic process
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0140268	Cellular component	endoplasmic reticulum-plasma membrane contact site
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043812	Molecular function	phosphatidylinositol-4-phosphate phosphatase activity
GO_0004438	Molecular function	phosphatidylinositol-3-phosphate phosphatase activity
GO_0016791	Molecular function	phosphatase activity
GO_0034596	Molecular function	phosphatidylinositol phosphate 4-phosphatase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SACM1L
Protein name	SAC1 like phosphatidylinositide phosphatase Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)
Synonyms	KIAA0851 hCG_15438 SAC1
Description	FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) . Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration . PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 . .
Accessions	E9PGZ4 A0A9L9PXK1 ENST00000706807.1 F8WCQ2 A0A9L9PXC7 F8WDN7 ENST00000438671.4 [Q9NTJ5-2] A0A9L9PXY7 A0A9L9PXZ2 ENST00000706817.1 ENST00000418611.5 A0A9L9PXB9 ENST00000441228.5 ENST00000706813.1 Q9NTJ5 A0A9L9PXJ6 A0A5F9ZHN7 ENST00000706815.1 A0A9L9PYD8 ENST00000455997.5 ENST00000706803.1 ENST00000706821.1 ENST00000478586.4 A0A9L9PXW5 A0A9L9PXW1 A0A9L9PYD2 ENST00000706806.1 ENST00000672858.2 ENST00000389061.10 [Q9NTJ5-1] ENST00000706810.1 A0A9L9PXJ1 ENST00000706822.1 ENST00000706825.1 ENST00000706816.1 ENST00000438671.4 ENST00000445499.3 C9J3E3 ENST00000706811.1 A0A9L9PXW9 ENST00000706818.1

SACM1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review