RNF139 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070613Biological processregulation of protein processing
GO_0031648Biological processprotein destabilization
GO_0060628Biological processregulation of ER to Golgi vesicle-mediated transport
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0017148Biological processnegative regulation of translation
GO_0012505Cellular componentendomembrane system
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0038023Molecular functionsignaling receptor activity
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0002020Molecular functionprotease binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF139
Protein nameE3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)
Ring finger protein 139
SynonymsTRC8
DescriptionFUNCTION: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death . Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) . Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression . Involved in the sterol-accelerated degradation of HMGCR . This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane . In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR . The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction . Required for INSIG1 ubiquitination . May be required for EIF3 complex ubiquitination . .

AccessionsQ8WU17
E5RH85
ENST00000517684.2
ENST00000303545.4
ENST00000708475.1