RNF111 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0070911Biological processglobal genome nucleotide-excision repair
GO_0000209Biological processprotein polyubiquitination
GO_0007389Biological processpattern specification process
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0032184Molecular functionSUMO polymer binding
GO_0046332Molecular functionSMAD binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF111
Protein nameRing finger protein 111
Alternative protein RNF111
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase . Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP . Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP . In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL . Associates with UBE2D2 as an E2 enzyme . Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates . Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair . Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). .

AccessionsQ6ZNA4
ENST00000559160.1
ENST00000557998.5 [Q6ZNA4-1]
ENST00000348370.9 [Q6ZNA4-2]
H0YKK5
L0R5C6
ENST00000561186.5 [Q6ZNA4-3]
ENST00000559209.5 [Q6ZNA4-4]
ENST00000559757.1
ENST00000559592.1
H0YLK9
H0YKS2