PTPRS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021766Biological processhippocampus development
GO_0006470Biological processprotein dephosphorylation
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0099537Biological processtrans-synaptic signaling
GO_0061000Biological processnegative regulation of dendritic spine development
GO_0021510Biological processspinal cord development
GO_0032687Biological processnegative regulation of interferon-alpha production
GO_0099560Biological processsynaptic membrane adhesion
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0022038Biological processcorpus callosum development
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0021549Biological processcerebellum development
GO_0034164Biological processnegative regulation of toll-like receptor 9 signaling pathway
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0030517Biological processnegative regulation of axon extension
GO_0021987Biological processcerebral cortex development
GO_0048681Biological processnegative regulation of axon regeneration
GO_0048671Biological processnegative regulation of collateral sprouting
GO_0099151Biological processregulation of postsynaptic density assembly
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0042734Cellular componentpresynaptic membrane
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0030424Cellular componentaxon
GO_0008201Molecular functionheparin binding
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0043395Molecular functionheparan sulfate proteoglycan binding
GO_0035374Molecular functionchondroitin sulfate binding
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRS
Protein namePTPRS protein (Protein tyrosine phosphatase receptor type S)
Alternative protein PTPRS
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Receptor-type tyrosine-protein phosphatase F
protein-tyrosine-phosphatase (EC 3.1.3.48)
Synonyms
DescriptionFUNCTION: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan . Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase . Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta . .

AccessionsG8JL96
ENST00000262963.11 [Q13332-1]
Q13332
ENST00000588012.5 [Q13332-6]
L8E8Y3
ENST00000262963
ENST00000590509.5
ENST00000592099.5 [Q13332-7]
A8E4L7
L8EAN4
Q8NHS7
ENST00000587303.5 [Q13332-1]