PTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_0044849Biological processestrous cycle
GO_0031641Biological processregulation of myelination
GO_0010996Biological processresponse to auditory stimulus
GO_0051781Biological processpositive regulation of cell division
GO_2000347Biological processpositive regulation of hepatocyte proliferation
GO_0043932Biological processossification involved in bone remodeling
GO_0010976Biological processpositive regulation of neuron projection development
GO_0007612Biological processlearning
GO_0046697Biological processdecidualization
GO_0031104Biological processdendrite regeneration
GO_0010594Biological processregulation of endothelial cell migration
GO_2000036Biological processregulation of stem cell population maintenance
GO_0042246Biological processtissue regeneration
GO_0043113Biological processreceptor clustering
GO_0048167Biological processregulation of synaptic plasticity
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0007185Biological processcell surface receptor protein tyrosine phosphatase signaling pathway
GO_1900006Biological processpositive regulation of dendrite development
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0048680Biological processpositive regulation of axon regeneration
GO_0030282Biological processbone mineralization
GO_0140059Biological processdendrite arborization
GO_0007613Biological processmemory
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0002232Biological processleukocyte chemotaxis involved in inflammatory response
GO_0045778Biological processpositive regulation of ossification
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0030501Biological processpositive regulation of bone mineralization
GO_0048477Biological processoogenesis
GO_0007399Biological processnervous system development
GO_0002690Biological processpositive regulation of leukocyte chemotaxis
GO_0007406Biological processnegative regulation of neuroblast proliferation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0008201Molecular functionheparin binding
GO_0140677Molecular functionmolecular function activator activity
GO_0019901Molecular functionprotein kinase binding
GO_0030246Molecular functioncarbohydrate binding
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0035374Molecular functionchondroitin sulfate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTN
Protein namePleiotrophin
Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)
SynonymsHBNF1
NEGF1
DescriptionFUNCTION: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors . Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups . Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone . Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway . Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway . Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation . In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation . Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). .

AccessionsC9JR52
P21246
ENST00000348225.7
A0A8V8TNI1
ENST00000393083.2
ENST00000699293.1