PTK6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTK6 at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0071300Biological processcellular response to retinoic acid
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0010976Biological processpositive regulation of neuron projection development
GO_0045087Biological processinnate immune response
GO_0038128Biological processERBB2 signaling pathway
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0045740Biological processpositive regulation of DNA replication
GO_0030154Biological processcell differentiation
GO_0061099Biological processnegative regulation of protein tyrosine kinase activity
GO_0006468Biological processprotein phosphorylation
GO_0060575Biological processintestinal epithelial cell differentiation
GO_0046777Biological processprotein autophosphorylation
GO_0045926Biological processnegative regulation of growth
GO_0016477Biological processcell migration
GO_0045787Biological processpositive regulation of cell cycle
GO_0001726Cellular componentruffle
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTK6
Protein nameProtein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
SynonymsBRK
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.; FUNCTION: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.

AccessionsQ13882
ENST00000542869.3 [Q13882-1]
ENST00000217185.3 [Q13882-2]