PSME4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0010499Biological processproteasomal ubiquitin-independent protein catabolic process
GO_0035092Biological processsperm DNA condensation
GO_0006281Biological processDNA repair
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990111Cellular componentspermatoproteasome complex
GO_0005634Cellular componentnucleus
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0070628Molecular functionproteasome binding
GO_0016504Molecular functionpeptidase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSME4
Protein nameProteasome activator subunit 4
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Proteasome activator complex subunit 4
SynonymsKIAA0077
DescriptionFUNCTION: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. .

AccessionsG1UI18
ENST00000404125.6 [Q14997-1]
Q14997
F8WBH5
ENST00000389993.7