PSMC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0001649Biological processosteoblast differentiation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0000932Cellular componentP-body
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0005737Cellular componentcytoplasm
GO_0022624Cellular componentproteasome accessory complex
GO_0005634Cellular componentnucleus
GO_0036402Molecular functionproteasome-activating activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene namePSMC2
Protein name26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Proteasome 26S subunit, ATPase 2
SynonymsMSS1
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

AccessionsA0A7I2YQ68
ENST00000457587.5
P35998
ENST00000679341.1 [P35998-1]
ENST00000679205.1 [P35998-1]
C9JX88
Q75L23
ENST00000678493.1 [P35998-1]
ENST00000678488.1
ENST00000435765.5 [P35998-1]
ENST00000679250.1 [P35998-2]
ENST00000292644.5 [P35998-1]
C9JLS9
ENST00000425206.6