PRKX | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	25 studies	32% ± 12%	Explore
natural killer cell	19 studies	22% ± 6%	Explore
endothelial cell	11 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	17% ± 2%	Explore
T cell	8 studies	18% ± 3%	Explore
CD4-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
gamma-delta T cell	7 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	6 studies	21% ± 5%	Explore
mature NK T cell	6 studies	20% ± 3%	Explore
microglial cell	6 studies	23% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 7%	Explore
dendritic cell	5 studies	22% ± 11%	Explore
macrophage	5 studies	26% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	16% ± 1%	Explore
neuron	4 studies	21% ± 3%	Explore
epithelial cell	4 studies	35% ± 18%	Explore
mucosal invariant T cell	4 studies	18% ± 2%	Explore
lymphocyte	4 studies	35% ± 10%	Explore
innate lymphoid cell	4 studies	31% ± 10%	Explore
memory B cell	4 studies	18% ± 3%	Explore
endothelial cell of artery	4 studies	24% ± 8%	Explore
basal cell	4 studies	29% ± 11%	Explore
interneuron	4 studies	24% ± 9%	Explore
astrocyte	4 studies	33% ± 15%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 8%	Explore
B cell	3 studies	18% ± 2%	Explore
myeloid cell	3 studies	32% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
GABAergic neuron	3 studies	24% ± 4%	Explore
glutamatergic neuron	3 studies	24% ± 9%	Explore
oligodendrocyte	3 studies	29% ± 1%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	25% ± 9%	Explore
peripheral blood	3 studies	25% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	7955.19	653 / 653	100%	35.27	603 / 605
ovary	100%	1153.49	180 / 180	99%	39.68	426 / 430
uterus	100%	1137.59	170 / 170	95%	31.80	438 / 459
esophagus	96%	1787.77	1390 / 1445	98%	28.26	180 / 183
lung	100%	2751.55	578 / 578	94%	25.90	1089 / 1155
intestine	97%	1241.16	933 / 966	95%	16.59	499 / 527
kidney	100%	2261.99	89 / 89	91%	19.88	822 / 901
stomach	94%	654.38	336 / 359	94%	17.70	270 / 286
breast	100%	1433.12	457 / 459	88%	17.96	986 / 1118
prostate	98%	1206.29	240 / 245	90%	9.26	450 / 502
bladder	95%	726.76	20 / 21	91%	15.38	460 / 504
brain	88%	961.51	2312 / 2642	97%	27.00	686 / 705
pancreas	89%	645.45	293 / 328	90%	11.16	161 / 178
skin	100%	1985.55	1809 / 1809	69%	9.04	326 / 472
adipose	100%	1355.45	1204 / 1204	0%	0	0 / 0
spleen	100%	2896.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.00	45 / 45
lymph node	0%	0	0 / 0	97%	18.13	28 / 29
blood vessel	91%	710.10	1221 / 1335	0%	0	0 / 0
peripheral blood	86%	1758.48	798 / 929	0%	0	0 / 0
heart	80%	486.25	690 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	71%	6.85	57 / 80
liver	28%	142.75	63 / 226	26%	3.74	106 / 406
adrenal gland	26%	115.91	66 / 258	14%	1.14	32 / 230
muscle	20%	94.12	158 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0001525	Biological process	angiogenesis
GO_0031589	Biological process	cell-substrate adhesion
GO_0010737	Biological process	protein kinase A signaling
GO_0007155	Biological process	cell adhesion
GO_0030099	Biological process	myeloid cell differentiation
GO_0043542	Biological process	endothelial cell migration
GO_0030334	Biological process	regulation of cell migration
GO_0001935	Biological process	endothelial cell proliferation
GO_0060993	Biological process	kidney morphogenesis
GO_2000696	Biological process	regulation of epithelial cell differentiation involved in kidney development
GO_0046777	Biological process	protein autophosphorylation
GO_0060562	Biological process	epithelial tube morphogenesis
GO_0030155	Biological process	regulation of cell adhesion
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0106310	Molecular function	protein serine kinase activity
GO_0004691	Molecular function	cAMP-dependent protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRKX
Protein name	cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Synonyms	PKX1
Description	FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. .
Accessions	ENST00000262848.6 P51817

PRKX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review