PRKRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042473Biological processouter ear morphogenesis
GO_0035196Biological processmiRNA processing
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009615Biological processresponse to virus
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0031054Biological processpre-miRNA processing
GO_0006955Biological processimmune response
GO_0034599Biological processcellular response to oxidative stress
GO_0050821Biological processprotein stabilization
GO_0030422Biological processsiRNA processing
GO_0070922Biological processRISC complex assembly
GO_0042474Biological processmiddle ear morphogenesis
GO_0070920Biological processregulation of regulatory ncRNA processing
GO_0048705Biological processskeletal system morphogenesis
GO_0140374Biological processantiviral innate immune response
GO_0070578Cellular componentRISC-loading complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0008047Molecular functionenzyme activator activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0035197Molecular functionsiRNA binding
GO_0070883Molecular functionpre-miRNA binding
GO_0042802Molecular functionidentical protein binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene namePRKRA
Protein nameProtein activator of interferon induced protein kinase EIF2AK2
Protein activator of interferon induced protein kinase EIF2AK2 (cDNA FLJ60590, highly similar to Interferon-inducible double strandedRNA-dependent protein kinase activator A)
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)
Protein activator of interferon induced protein kinase EIF2AK2 (Protein kinase, interferon-inducible double stranded RNA dependent activator, isoform CRA_d)
SynonymshCG_43233
PACT
RAX
HSD14
HSD-14
DescriptionFUNCTION: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). .

AccessionsENST00000677206.1
A0A7I2V5C2
ENST00000677689.1
ENST00000325748.9 [O75569-1]
A0A7I2V3J2
ENST00000676505.1
ENST00000678167.1
O75569
G5E9Q4
A0A7I2V593
A0A7I2V5H3
A0A7I2YQ87
A0A7I2YQP2
ENST00000678053.1
F8WEG8
ENST00000677981.1
ENST00000677584.1
ENST00000678058.1
ENST00000432031.6 [O75569-2]
B4DJC7
ENST00000677460.1
ENST00000678775.1
ENST00000424699.5
A0A7I2V2P4
ENST00000677386.1
A0A7I2V315
ENST00000676922.1
ENST00000676832.1
A0A7I2V2I8
A0A7I2V332
ENST00000457633.2
ENST00000448279.2
ENST00000677253.1
ENST00000677859.1
A0A7I2V3L6
ENST00000678845.1
C9JMM3
ENST00000679037.1
ENST00000487082.5 [O75569-3]