Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 24% ± 7% | |
pericyte | 10 studies | 21% ± 5% | |
fibroblast | 8 studies | 22% ± 7% | |
plasmacytoid dendritic cell | 8 studies | 24% ± 7% | |
smooth muscle cell | 7 studies | 21% ± 6% | |
epithelial cell | 7 studies | 30% ± 14% | |
connective tissue cell | 6 studies | 23% ± 5% | |
astrocyte | 6 studies | 24% ± 6% | |
basal cell | 6 studies | 26% ± 9% | |
neuron | 5 studies | 30% ± 14% | |
retinal rod cell | 5 studies | 26% ± 6% | |
B cell | 4 studies | 19% ± 5% | |
myofibroblast cell | 4 studies | 20% ± 3% | |
ciliated cell | 4 studies | 30% ± 10% | |
glutamatergic neuron | 4 studies | 50% ± 16% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 6% | |
interneuron | 4 studies | 33% ± 20% | |
oligodendrocyte | 4 studies | 22% ± 4% | |
type B pancreatic cell | 3 studies | 31% ± 6% | |
conventional dendritic cell | 3 studies | 27% ± 8% | |
microglial cell | 3 studies | 19% ± 3% | |
retinal cone cell | 3 studies | 33% ± 14% | |
macrophage | 3 studies | 18% ± 0% | |
GABAergic neuron | 3 studies | 51% ± 3% | |
dendritic cell | 3 studies | 32% ± 12% | |
abnormal cell | 3 studies | 24% ± 7% | |
intestinal crypt stem cell | 3 studies | 19% ± 4% | |
transit amplifying cell | 3 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2456.71 | 1445 / 1445 | 100% | 9.98 | 183 / 183 |
ovary | 100% | 2244.04 | 180 / 180 | 100% | 9.37 | 428 / 430 |
stomach | 100% | 1824.96 | 359 / 359 | 99% | 6.92 | 284 / 286 |
lung | 100% | 2018.94 | 577 / 578 | 99% | 8.09 | 1148 / 1155 |
intestine | 100% | 2494.95 | 966 / 966 | 99% | 6.39 | 520 / 527 |
brain | 100% | 1979.69 | 2636 / 2642 | 99% | 8.66 | 696 / 705 |
breast | 100% | 2446.29 | 459 / 459 | 98% | 8.64 | 1096 / 1118 |
pancreas | 100% | 1242.59 | 328 / 328 | 96% | 5.44 | 171 / 178 |
prostate | 100% | 2419.52 | 245 / 245 | 95% | 5.94 | 476 / 502 |
skin | 100% | 2376.75 | 1809 / 1809 | 94% | 6.93 | 445 / 472 |
uterus | 100% | 2543.65 | 170 / 170 | 93% | 6.39 | 429 / 459 |
thymus | 100% | 2077.01 | 652 / 653 | 94% | 5.73 | 566 / 605 |
kidney | 100% | 2103.10 | 89 / 89 | 92% | 5.49 | 827 / 901 |
bladder | 100% | 2818.71 | 21 / 21 | 91% | 5.72 | 461 / 504 |
adrenal gland | 100% | 1809.81 | 258 / 258 | 84% | 4.79 | 193 / 230 |
liver | 100% | 1005.00 | 226 / 226 | 42% | 1.48 | 172 / 406 |
adipose | 100% | 2383.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3367.60 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4579.53 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1493.86 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 1774.43 | 845 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 6.16 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 76% | 4.34 | 22 / 29 |
eye | 0% | 0 | 0 / 0 | 73% | 3.12 | 58 / 80 |
peripheral blood | 49% | 899.21 | 455 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042473 | Biological process | outer ear morphogenesis |
GO_0035196 | Biological process | miRNA processing |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0009615 | Biological process | response to virus |
GO_2001244 | Biological process | positive regulation of intrinsic apoptotic signaling pathway |
GO_0031054 | Biological process | pre-miRNA processing |
GO_0006955 | Biological process | immune response |
GO_0034599 | Biological process | cellular response to oxidative stress |
GO_0050821 | Biological process | protein stabilization |
GO_0030422 | Biological process | siRNA processing |
GO_0070922 | Biological process | RISC complex assembly |
GO_0042474 | Biological process | middle ear morphogenesis |
GO_0070920 | Biological process | regulation of regulatory ncRNA processing |
GO_0048705 | Biological process | skeletal system morphogenesis |
GO_0140374 | Biological process | antiviral innate immune response |
GO_0070578 | Cellular component | RISC-loading complex |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0016442 | Cellular component | RISC complex |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0008047 | Molecular function | enzyme activator activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0035197 | Molecular function | siRNA binding |
GO_0070883 | Molecular function | pre-miRNA binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0030295 | Molecular function | protein kinase activator activity |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003725 | Molecular function | double-stranded RNA binding |
Gene name | PRKRA |
Protein name | Protein activator of interferon induced protein kinase EIF2AK2 Protein activator of interferon induced protein kinase EIF2AK2 (cDNA FLJ60590, highly similar to Interferon-inducible double strandedRNA-dependent protein kinase activator A) Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) Protein activator of interferon induced protein kinase EIF2AK2 (Protein kinase, interferon-inducible double stranded RNA dependent activator, isoform CRA_d) |
Synonyms | hCG_43233 PACT RAX HSD14 HSD-14 |
Description | FUNCTION: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). . |
Accessions | ENST00000677206.1 A0A7I2V5C2 ENST00000677689.1 ENST00000325748.9 [O75569-1] A0A7I2V3J2 ENST00000676505.1 ENST00000678167.1 O75569 G5E9Q4 A0A7I2V593 A0A7I2V5H3 A0A7I2YQ87 A0A7I2YQP2 ENST00000678053.1 F8WEG8 ENST00000677981.1 ENST00000677584.1 ENST00000678058.1 ENST00000432031.6 [O75569-2] B4DJC7 ENST00000677460.1 ENST00000678775.1 ENST00000424699.5 A0A7I2V2P4 ENST00000677386.1 A0A7I2V315 ENST00000676922.1 ENST00000676832.1 A0A7I2V2I8 A0A7I2V332 ENST00000457633.2 ENST00000448279.2 ENST00000677253.1 ENST00000677859.1 A0A7I2V3L6 ENST00000678845.1 C9JMM3 ENST00000679037.1 ENST00000487082.5 [O75569-3] |