PRKAG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006469Biological processnegative regulation of protein kinase activity
GO_0006754Biological processATP biosynthetic process
GO_0005977Biological processglycogen metabolic process
GO_0019217Biological processregulation of fatty acid metabolic process
GO_0006110Biological processregulation of glycolytic process
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0031669Biological processcellular response to nutrient levels
GO_0006633Biological processfatty acid biosynthetic process
GO_0035556Biological processintracellular signal transduction
GO_0050790Biological processregulation of catalytic activity
GO_0016126Biological processsterol biosynthetic process
GO_0006468Biological processprotein phosphorylation
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0046324Biological processregulation of glucose import
GO_0046320Biological processregulation of fatty acid oxidation
GO_0005615Cellular componentextracellular space
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043531Molecular functionADP binding
GO_0004862Molecular functioncAMP-dependent protein kinase inhibitor activity
GO_0019887Molecular functionprotein kinase regulator activity
GO_0008603Molecular functioncAMP-dependent protein kinase regulator activity
GO_0016208Molecular functionAMP binding
GO_0019901Molecular functionprotein kinase binding
GO_0008607Molecular functionphosphorylase kinase regulator activity
GO_0030295Molecular functionprotein kinase activator activity
GO_0004679Molecular functionAMP-activated protein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKAG2
Protein name5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)
Protein kinase AMP-activated non-catalytic subunit gamma 2
Epididymis secretory sperm binding protein (Protein kinase, AMP-activated, gamma 2 non-catalytic subunit, isoform CRA_b)
Protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Alternative protein PRKAG2
Synonymstcag7.766
hCG_2043270
DescriptionFUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation . AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators . Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin . Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits . ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit . ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive . .

AccessionsENST00000652707.1
A0A7R6M8M9
ENST00000476632.2 [Q9UGJ0-2]
ENST00000492843.6
ENST00000652397.1
A0A494C155
A0A494C094
A0A494C1R6
A0A384MDZ2
A0A494C1K7
ENST00000651836.1
ENST00000652321.2
ENST00000651188.1
ENST00000488258.5
ENST00000478989.7
F8WAY3
A0A494C188
A0A7R6M8E2
ENST00000392801.6 [Q9UGJ0-3]
ENST00000652159.1 [Q9UGJ0-3]
ENST00000651378.1 [Q9UGJ0-2]
ENST00000651764.1 [Q9UGJ0-3]
L8E9N3
A0A494C0H7
E9PGP6
A0A494C026
A0A090N8Q6
F8WDA1
ENST00000652047.1
A0A494C068
ENST00000287878.9 [Q9UGJ0-1]
F8WDB5
ENST00000418337.6 [Q9UGJ0-2]
ENST00000651303.1
ENST00000493872.5
ENST00000650858.1
Q9UGJ0