Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 16 studies | 37% ± 19% | |
| endothelial cell | 14 studies | 27% ± 12% | |
| glutamatergic neuron | 13 studies | 49% ± 26% | |
| classical monocyte | 12 studies | 27% ± 10% | |
| microglial cell | 12 studies | 42% ± 15% | |
| fibroblast | 10 studies | 25% ± 9% | |
| adipocyte | 9 studies | 49% ± 14% | |
| smooth muscle cell | 8 studies | 26% ± 11% | |
| myeloid cell | 8 studies | 39% ± 16% | |
| astrocyte | 8 studies | 33% ± 17% | |
| monocyte | 7 studies | 32% ± 16% | |
| non-classical monocyte | 7 studies | 28% ± 11% | |
| dendritic cell | 7 studies | 35% ± 12% | |
| mast cell | 7 studies | 28% ± 9% | |
| endothelial cell of lymphatic vessel | 7 studies | 43% ± 15% | |
| GABAergic neuron | 7 studies | 43% ± 21% | |
| interneuron | 6 studies | 34% ± 14% | |
| cardiac muscle cell | 6 studies | 54% ± 15% | |
| natural killer cell | 5 studies | 18% ± 3% | |
| neuron | 5 studies | 33% ± 11% | |
| retinal ganglion cell | 5 studies | 34% ± 10% | |
| epithelial cell | 5 studies | 38% ± 16% | |
| oligodendrocyte precursor cell | 5 studies | 27% ± 11% | |
| type II pneumocyte | 5 studies | 24% ± 6% | |
| basal cell | 5 studies | 21% ± 6% | |
| hepatocyte | 4 studies | 62% ± 26% | |
| effector memory CD8-positive, alpha-beta T cell | 4 studies | 17% ± 3% | |
| granule cell | 4 studies | 39% ± 13% | |
| B cell | 4 studies | 18% ± 5% | |
| club cell | 4 studies | 26% ± 8% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 2% | |
| conventional dendritic cell | 3 studies | 25% ± 10% | |
| GABAergic interneuron | 3 studies | 22% ± 3% | |
| mesothelial cell | 3 studies | 20% ± 4% | |
| mononuclear phagocyte | 3 studies | 29% ± 10% | |
| ciliated cell | 3 studies | 31% ± 17% | |
| lymphocyte | 3 studies | 28% ± 11% | |
| muscle cell | 3 studies | 34% ± 16% | |
| T cell | 3 studies | 20% ± 3% | |
| alveolar macrophage | 3 studies | 41% ± 12% | |
| respiratory goblet cell | 3 studies | 28% ± 12% | |
| pericyte | 3 studies | 22% ± 3% | |
| renal principal cell | 3 studies | 63% ± 27% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3293.21 | 244 / 245 | 100% | 10.81 | 501 / 502 |
| brain | 99% | 2930.42 | 2617 / 2642 | 99% | 8.63 | 699 / 705 |
| thymus | 99% | 1760.50 | 649 / 653 | 98% | 5.13 | 595 / 605 |
| breast | 100% | 2580.95 | 459 / 459 | 97% | 6.04 | 1089 / 1118 |
| ovary | 100% | 1406.12 | 180 / 180 | 97% | 5.75 | 415 / 430 |
| kidney | 100% | 2080.88 | 89 / 89 | 96% | 8.79 | 865 / 901 |
| lung | 99% | 1929.98 | 572 / 578 | 97% | 5.43 | 1120 / 1155 |
| intestine | 100% | 2869.08 | 966 / 966 | 94% | 4.91 | 493 / 527 |
| stomach | 100% | 2751.14 | 359 / 359 | 93% | 4.58 | 266 / 286 |
| esophagus | 100% | 3120.79 | 1444 / 1445 | 91% | 4.12 | 166 / 183 |
| uterus | 99% | 2114.06 | 169 / 170 | 86% | 4.40 | 397 / 459 |
| bladder | 100% | 5759.14 | 21 / 21 | 86% | 4.11 | 432 / 504 |
| liver | 100% | 2380.85 | 226 / 226 | 81% | 3.61 | 330 / 406 |
| pancreas | 82% | 750.54 | 270 / 328 | 96% | 4.81 | 171 / 178 |
| adrenal gland | 92% | 807.71 | 237 / 258 | 69% | 2.88 | 158 / 230 |
| skin | 100% | 2093.30 | 1805 / 1809 | 56% | 2.08 | 263 / 472 |
| adipose | 100% | 3153.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4041.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2122.59 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 97% | 9026.22 | 838 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 2.98 | 36 / 45 |
| muscle | 70% | 981.76 | 560 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 66% | 2.58 | 53 / 80 |
| peripheral blood | 57% | 498.12 | 525 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 1.71 | 14 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_0006754 | Biological process | ATP biosynthetic process |
| GO_0005977 | Biological process | glycogen metabolic process |
| GO_0019217 | Biological process | regulation of fatty acid metabolic process |
| GO_0006110 | Biological process | regulation of glycolytic process |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0031669 | Biological process | cellular response to nutrient levels |
| GO_0006633 | Biological process | fatty acid biosynthetic process |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0050790 | Biological process | regulation of catalytic activity |
| GO_0016126 | Biological process | sterol biosynthetic process |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0010800 | Biological process | positive regulation of peptidyl-threonine phosphorylation |
| GO_0046324 | Biological process | regulation of glucose import |
| GO_0046320 | Biological process | regulation of fatty acid oxidation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031588 | Cellular component | nucleotide-activated protein kinase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0043531 | Molecular function | ADP binding |
| GO_0004862 | Molecular function | cAMP-dependent protein kinase inhibitor activity |
| GO_0019887 | Molecular function | protein kinase regulator activity |
| GO_0008603 | Molecular function | cAMP-dependent protein kinase regulator activity |
| GO_0016208 | Molecular function | AMP binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0008607 | Molecular function | phosphorylase kinase regulator activity |
| GO_0030295 | Molecular function | protein kinase activator activity |
| GO_0004679 | Molecular function | AMP-activated protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PRKAG2 |
| Protein name | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) Protein kinase AMP-activated non-catalytic subunit gamma 2 Epididymis secretory sperm binding protein (Protein kinase, AMP-activated, gamma 2 non-catalytic subunit, isoform CRA_b) Protein kinase, AMP-activated, gamma 2 non-catalytic subunit Alternative protein PRKAG2 |
| Synonyms | tcag7.766 hCG_2043270 |
| Description | FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation . AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators . Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin . Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits . ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit . ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive . . |
| Accessions | ENST00000652707.1 A0A7R6M8M9 ENST00000476632.2 [Q9UGJ0-2] ENST00000492843.6 ENST00000652397.1 A0A494C155 A0A494C094 A0A494C1R6 A0A384MDZ2 A0A494C1K7 ENST00000651836.1 ENST00000652321.2 ENST00000651188.1 ENST00000488258.5 ENST00000478989.7 F8WAY3 A0A494C188 A0A7R6M8E2 ENST00000392801.6 [Q9UGJ0-3] ENST00000652159.1 [Q9UGJ0-3] ENST00000651378.1 [Q9UGJ0-2] ENST00000651764.1 [Q9UGJ0-3] L8E9N3 A0A494C0H7 E9PGP6 A0A494C026 A0A090N8Q6 F8WDA1 ENST00000652047.1 A0A494C068 ENST00000287878.9 [Q9UGJ0-1] F8WDB5 ENST00000418337.6 [Q9UGJ0-2] ENST00000651303.1 ENST00000493872.5 ENST00000650858.1 Q9UGJ0 |