PRKACA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0071333Biological processcellular response to glucose stimulus
GO_1904539Biological processnegative regulation of glycolytic process through fructose-6-phosphate
GO_0070613Biological processregulation of protein processing
GO_0006611Biological processprotein export from nucleus
GO_0006397Biological processmRNA processing
GO_0003091Biological processrenal water homeostasis
GO_0034605Biological processcellular response to heat
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0035694Biological processmitochondrial protein catabolic process
GO_0045667Biological processregulation of osteoblast differentiation
GO_0086064Biological processcell communication by electrical coupling involved in cardiac conduction
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0002027Biological processregulation of heart rate
GO_0010737Biological processprotein kinase A signaling
GO_0048240Biological processsperm capacitation
GO_0071374Biological processcellular response to parathyroid hormone stimulus
GO_0071872Biological processcellular response to epinephrine stimulus
GO_0032024Biological processpositive regulation of insulin secretion
GO_0070417Biological processcellular response to cold
GO_0010881Biological processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0034380Biological processhigh-density lipoprotein particle assembly
GO_0001707Biological processmesoderm formation
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0071377Biological processcellular response to glucagon stimulus
GO_0001843Biological processneural tube closure
GO_1990044Biological processprotein localization to lipid droplet
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0099170Biological processpostsynaptic modulation of chemical synaptic transmission
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_1903779Biological processregulation of cardiac conduction
GO_0016241Biological processregulation of macroautophagy
GO_0006468Biological processprotein phosphorylation
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0051726Biological processregulation of cell cycle
GO_0098978Cellular componentglutamatergic synapse
GO_0001669Cellular componentacrosomal vesicle
GO_0036126Cellular componentsperm flagellum
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005930Cellular componentaxoneme
GO_0044853Cellular componentplasma membrane raft
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0034704Cellular componentcalcium channel complex
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0005952Cellular componentcAMP-dependent protein kinase complex
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0030145Molecular functionmanganese ion binding
GO_0004691Molecular functioncAMP-dependent protein kinase activity
GO_0099103Molecular functionchannel activator activity
GO_0004679Molecular functionAMP-activated protein kinase activity
GO_0005524Molecular functionATP binding
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKACA
Protein namecAMP-dependent protein kinase catalytic subunit alpha
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Protein kinase A-alpha (Protein kinase cAMP-activated catalytic subunit alpha)
cAMP-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11)
Protein kinase cAMP-activated catalytic subunit alpha (cDNA FLJ58698, highly similar to cAMP-dependent protein kinase, alpha-catalytic subunit)
Protein kinase cAMP-activated catalytic subunit alpha
SynonymsPKACA
KIN27
DescriptionFUNCTION: Phosphorylates a large number of substrates in the cytoplasm and the nucleus . Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP . Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis . RORA is activated by phosphorylation . Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts . Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP . Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated . RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) . PSMC5/RPT6 activation by phosphorylation stimulates proteasome . Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation . NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding . Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis . Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA . Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock . Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR . .; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. .

AccessionsENST00000590853.5
ENST00000672938.1 [P17612-2]
K7ERP6
ENST00000308677.9 [P17612-1]
A0A7I2V5J4
ENST00000589994.6 [P17612-2]
ENST00000677971.1
ENST00000589284.1
A0A8V8TL59
P17612
K7ENJ5
K7EMV1
B7Z708
ENST00000350356.7
ENST00000587372.5
ENST00000673550.1 [P17612-1]
ENST00000593092.1
A0A7I2YQ82
Q15136
ENST00000536649.5
ENST00000677951.1