POLD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006271Biological processDNA strand elongation involved in DNA replication
GO_0071897Biological processDNA biosynthetic process
GO_0006260Biological processDNA replication
GO_0042276Biological processerror-prone translesion synthesis
GO_0006261Biological processDNA-templated DNA replication
GO_0005654Cellular componentnucleoplasm
GO_0043625Cellular componentdelta DNA polymerase complex
GO_0016035Cellular componentzeta DNA polymerase complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOLD2
Protein nameDNA polymerase delta subunit 2 (DNA polymerase delta subunit p50)
DNA polymerase delta subunit 2
DNA polymerase delta 2, accessory subunit
Synonyms
DescriptionFUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex . As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair . Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 . Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated . Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation . Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) . Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex . Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 . .

AccessionsA0A8V8TMJ5
ENST00000698961.1
A0A087WWF6
ENST00000610533.6
ENST00000698979.1
ENST00000223361.7
A0A8V8TPB6
ENST00000452185.5
C9JHC7
H7C1B3
A0A8V8TMZ6
A0A8V8TPA6
A0A8V8TN02
ENST00000436844.6
ENST00000698959.1
ENST00000698945.1
ENST00000698976.1
ENST00000698977.1
ENST00000433715.6
ENST00000698946.1
ENST00000698991.1
A0A8V8TN07
ENST00000698988.1
ENST00000698982.1
ENST00000610533
ENST00000698960.1
A0A8V8TNY7
A0A8V8TPA1
ENST00000698962.1
ENST00000436400.6
ENST00000698951.1
ENST00000418438.2
ENST00000698949.1
C9JLE1
P49005
ENST00000698978.1
ENST00000698955.1
A0A8V8TMJ0
C9IZD2
ENST00000698950.1
ENST00000418438.1
ENST00000698965.1
ENST00000406581.6
A0A8V8TMK0
ENST00000698989.1
ENST00000698947.1