Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 13 studies | 33% ± 15% | |
epithelial cell | 10 studies | 30% ± 13% | |
fibroblast | 9 studies | 25% ± 8% | |
smooth muscle cell | 9 studies | 22% ± 8% | |
myofibroblast cell | 7 studies | 20% ± 4% | |
basal cell | 7 studies | 26% ± 14% | |
plasmacytoid dendritic cell | 7 studies | 21% ± 5% | |
CD4-positive, alpha-beta T cell | 6 studies | 26% ± 11% | |
connective tissue cell | 6 studies | 25% ± 7% | |
pericyte | 6 studies | 23% ± 7% | |
CD8-positive, alpha-beta T cell | 6 studies | 23% ± 8% | |
progenitor cell | 5 studies | 20% ± 2% | |
erythroblast | 5 studies | 32% ± 14% | |
abnormal cell | 5 studies | 27% ± 10% | |
hematopoietic precursor cell | 4 studies | 31% ± 14% | |
mesothelial cell | 4 studies | 39% ± 13% | |
endothelial cell | 4 studies | 23% ± 11% | |
natural killer cell | 4 studies | 24% ± 5% | |
deuterosomal cell | 3 studies | 20% ± 4% | |
B cell | 3 studies | 23% ± 7% | |
neural crest cell | 3 studies | 25% ± 1% | |
dendritic cell | 3 studies | 30% ± 7% | |
enteroendocrine cell | 3 studies | 26% ± 11% | |
goblet cell | 3 studies | 26% ± 8% | |
intestinal crypt stem cell | 3 studies | 23% ± 2% | |
erythrocyte | 3 studies | 39% ± 14% | |
transit amplifying cell | 3 studies | 26% ± 8% | |
hematopoietic stem cell | 3 studies | 18% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4637.25 | 1445 / 1445 | 100% | 89.51 | 183 / 183 |
ovary | 100% | 4478.86 | 180 / 180 | 100% | 112.96 | 430 / 430 |
skin | 100% | 5292.53 | 1809 / 1809 | 100% | 152.71 | 472 / 472 |
uterus | 100% | 4116.49 | 170 / 170 | 100% | 140.40 | 458 / 459 |
brain | 100% | 2856.73 | 2636 / 2642 | 100% | 128.00 | 705 / 705 |
prostate | 100% | 3940.51 | 245 / 245 | 100% | 138.33 | 500 / 502 |
liver | 100% | 4475.26 | 226 / 226 | 100% | 85.79 | 404 / 406 |
intestine | 100% | 2957.15 | 966 / 966 | 99% | 131.75 | 524 / 527 |
stomach | 100% | 2946.86 | 359 / 359 | 99% | 104.94 | 284 / 286 |
breast | 100% | 3611.93 | 459 / 459 | 99% | 101.44 | 1107 / 1118 |
thymus | 100% | 3483.21 | 653 / 653 | 99% | 65.19 | 599 / 605 |
pancreas | 100% | 3093.25 | 328 / 328 | 99% | 69.24 | 176 / 178 |
lung | 100% | 2998.64 | 576 / 578 | 99% | 101.51 | 1146 / 1155 |
bladder | 100% | 3865.48 | 21 / 21 | 99% | 113.36 | 498 / 504 |
adrenal gland | 100% | 4214.43 | 258 / 258 | 99% | 78.51 | 227 / 230 |
kidney | 100% | 3524.90 | 89 / 89 | 98% | 84.76 | 887 / 901 |
adipose | 100% | 3537.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 131.29 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 147.89 | 29 / 29 |
muscle | 100% | 5092.46 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2846.30 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 135.68 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 40.88 | 1 / 1 |
blood vessel | 100% | 3813.26 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 4267.78 | 849 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 61% | 1998.32 | 568 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006271 | Biological process | DNA strand elongation involved in DNA replication |
GO_0071897 | Biological process | DNA biosynthetic process |
GO_0006260 | Biological process | DNA replication |
GO_0042276 | Biological process | error-prone translesion synthesis |
GO_0006261 | Biological process | DNA-templated DNA replication |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043625 | Cellular component | delta DNA polymerase complex |
GO_0016035 | Cellular component | zeta DNA polymerase complex |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | POLD2 |
Protein name | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) DNA polymerase delta subunit 2 DNA polymerase delta 2, accessory subunit |
Synonyms | |
Description | FUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex . As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair . Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 . Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated . Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation . Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) . Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex . Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 . . |
Accessions | A0A8V8TMJ5 ENST00000698961.1 A0A087WWF6 ENST00000610533.6 ENST00000698979.1 ENST00000223361.7 A0A8V8TPB6 ENST00000452185.5 C9JHC7 H7C1B3 A0A8V8TMZ6 A0A8V8TPA6 A0A8V8TN02 ENST00000436844.6 ENST00000698959.1 ENST00000698945.1 ENST00000698976.1 ENST00000698977.1 ENST00000433715.6 ENST00000698946.1 ENST00000698991.1 A0A8V8TN07 ENST00000698988.1 ENST00000698982.1 ENST00000610533 ENST00000698960.1 A0A8V8TNY7 A0A8V8TPA1 ENST00000698962.1 ENST00000436400.6 ENST00000698951.1 ENST00000418438.2 ENST00000698949.1 C9JLE1 P49005 ENST00000698978.1 ENST00000698955.1 A0A8V8TMJ0 C9IZD2 ENST00000698950.1 ENST00000418438.1 ENST00000698965.1 ENST00000406581.6 A0A8V8TMK0 ENST00000698989.1 ENST00000698947.1 |