POLA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0006269Biological processDNA replication, synthesis of primer
GO_0006273Biological processlagging strand elongation
GO_0006289Biological processnucleotide-excision repair
GO_0006260Biological processDNA replication
GO_0032479Biological processregulation of type I interferon production
GO_1904161Biological processDNA synthesis involved in UV-damage excision repair
GO_0006272Biological processleading strand elongation
GO_0006270Biological processDNA replication initiation
GO_0000731Biological processDNA synthesis involved in DNA repair
GO_0006271Biological processDNA strand elongation involved in DNA replication
GO_1902975Biological processmitotic DNA replication initiation
GO_0005730Cellular componentnucleolus
GO_0005658Cellular componentalpha DNA polymerase:primase complex
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0003688Molecular functionDNA replication origin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0000166Molecular functionnucleotide binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOLA1
Protein nameDNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)
DNA polymerase (EC 2.7.7.7)
DNA polymerase alpha 1, catalytic subunit
Alternative protein POLA1
SynonymsPOLA
DescriptionFUNCTION: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses . .

AccessionsA0A7I2V2V3
ENST00000677890.1
ENST00000672178.1
ENST00000379059.7
A0A5F9ZHW2
L8ECG9
ENST00000379068.8
A6NMQ1
P09884