PMVK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	12 studies	22% ± 4%	Explore
plasma cell	9 studies	25% ± 12%	Explore
CD4-positive, alpha-beta T cell	9 studies	22% ± 8%	Explore
basal cell	9 studies	24% ± 14%	Explore
type I pneumocyte	7 studies	23% ± 12%	Explore
non-classical monocyte	7 studies	26% ± 10%	Explore
macrophage	7 studies	23% ± 7%	Explore
pericyte	7 studies	19% ± 4%	Explore
epithelial cell	7 studies	39% ± 18%	Explore
B cell	5 studies	24% ± 6%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 4%	Explore
kidney loop of Henle epithelial cell	5 studies	25% ± 6%	Explore
abnormal cell	5 studies	30% ± 12%	Explore
fibroblast	5 studies	29% ± 12%	Explore
smooth muscle cell	5 studies	24% ± 8%	Explore
T cell	5 studies	22% ± 7%	Explore
endothelial cell	5 studies	26% ± 12%	Explore
ciliated cell	5 studies	28% ± 9%	Explore
CD8-positive, alpha-beta T cell	5 studies	18% ± 3%	Explore
plasmablast	4 studies	46% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 4%	Explore
enterocyte	4 studies	19% ± 2%	Explore
astrocyte	4 studies	24% ± 9%	Explore
pancreatic A cell	3 studies	38% ± 15%	Explore
conventional dendritic cell	3 studies	29% ± 6%	Explore
hematopoietic precursor cell	3 studies	31% ± 5%	Explore
retinal ganglion cell	3 studies	62% ± 22%	Explore
connective tissue cell	3 studies	22% ± 3%	Explore
myofibroblast cell	3 studies	16% ± 0%	Explore
retina horizontal cell	3 studies	27% ± 10%	Explore
Mueller cell	3 studies	28% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
dendritic cell	3 studies	37% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 5%	Explore
enteroendocrine cell	3 studies	28% ± 15%	Explore
T-helper 17 cell	3 studies	23% ± 8%	Explore
plasmacytoid dendritic cell	3 studies	20% ± 3%	Explore
natural killer cell	3 studies	22% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	16% ± 1%	Explore
hepatocyte	3 studies	33% ± 23%	Explore
neuron	3 studies	28% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	5 studies	20% ± 6%	Explore
kidney	4 studies	18% ± 1%	Explore
lung	4 studies	23% ± 2%	Explore
peripheral blood	3 studies	19% ± 5%	Explore
brain	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2736.06	2642 / 2642	100%	230.99	705 / 705
liver	100%	2575.90	226 / 226	100%	264.10	406 / 406
uterus	100%	1606.18	170 / 170	100%	236.15	459 / 459
skin	100%	2798.16	1809 / 1809	100%	172.64	471 / 472
ovary	100%	1881.08	180 / 180	100%	130.90	429 / 430
thymus	100%	1905.09	651 / 653	100%	212.82	605 / 605
kidney	100%	2583.58	89 / 89	100%	168.69	897 / 901
esophagus	100%	2677.46	1445 / 1445	99%	97.33	182 / 183
prostate	100%	1892.51	245 / 245	99%	202.87	498 / 502
pancreas	100%	1023.22	327 / 328	99%	169.81	177 / 178
stomach	100%	1748.67	359 / 359	99%	93.33	283 / 286
intestine	100%	1976.05	966 / 966	99%	107.11	521 / 527
breast	100%	1788.73	459 / 459	99%	242.90	1104 / 1118
bladder	100%	1801.95	21 / 21	98%	166.66	494 / 504
lung	99%	1542.83	574 / 578	99%	140.76	1140 / 1155
adrenal gland	100%	2938.47	258 / 258	98%	210.89	225 / 230
adipose	100%	1649.77	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	179.44	80 / 80
lymph node	0%	0	0 / 0	100%	293.63	29 / 29
spleen	100%	2513.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	215.33	45 / 45
ureter	0%	0	0 / 0	100%	214.51	1 / 1
blood vessel	100%	1799.13	1332 / 1335	0%	0	0 / 0
muscle	99%	1306.19	792 / 803	0%	0	0 / 0
heart	98%	2194.86	846 / 861	0%	0	0 / 0
peripheral blood	78%	1181.37	728 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070723	Biological process	response to cholesterol
GO_0016126	Biological process	sterol biosynthetic process
GO_0006695	Biological process	cholesterol biosynthetic process
GO_0019287	Biological process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005777	Cellular component	peroxisome
GO_0016020	Cellular component	membrane
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0004631	Molecular function	phosphomevalonate kinase activity

IV. Literature review

[source]

Gene name	PMVK
Protein name	Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2) Phosphomevalonate kinase (EC 2.7.4.2)
Synonyms	hCG_1739272 PMKI
Description	FUNCTION: Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. .
Accessions	Q15126 ENST00000368467.4 Q6FGV9

PMVK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review