PLEKHA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	25 studies	28% ± 11%	Explore
naive B cell	19 studies	31% ± 11%	Explore
macrophage	17 studies	29% ± 16%	Explore
natural killer cell	15 studies	22% ± 6%	Explore
pericyte	10 studies	27% ± 11%	Explore
microglial cell	9 studies	35% ± 12%	Explore
myeloid cell	9 studies	30% ± 12%	Explore
memory B cell	8 studies	23% ± 12%	Explore
mast cell	8 studies	26% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	25% ± 6%	Explore
fibroblast	7 studies	27% ± 10%	Explore
monocyte	7 studies	24% ± 6%	Explore
oligodendrocyte precursor cell	7 studies	37% ± 15%	Explore
CD8-positive, alpha-beta T cell	6 studies	21% ± 5%	Explore
dendritic cell	6 studies	29% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 5%	Explore
non-classical monocyte	5 studies	23% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
mature NK T cell	5 studies	20% ± 3%	Explore
endothelial cell	5 studies	27% ± 7%	Explore
precursor B cell	5 studies	35% ± 12%	Explore
immature B cell	5 studies	48% ± 19%	Explore
T cell	5 studies	25% ± 13%	Explore
gamma-delta T cell	5 studies	24% ± 8%	Explore
smooth muscle cell	5 studies	19% ± 2%	Explore
classical monocyte	4 studies	23% ± 7%	Explore
leukocyte	4 studies	29% ± 6%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
cardiac muscle cell	4 studies	26% ± 3%	Explore
lymphocyte	4 studies	38% ± 16%	Explore
retina horizontal cell	4 studies	24% ± 4%	Explore
mucosal invariant T cell	3 studies	20% ± 2%	Explore
epithelial cell	3 studies	33% ± 9%	Explore
germinal center B cell	3 studies	29% ± 5%	Explore
glutamatergic neuron	3 studies	34% ± 4%	Explore
alveolar macrophage	3 studies	33% ± 10%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 7%	Explore
astrocyte	3 studies	29% ± 3%	Explore
abnormal cell	3 studies	20% ± 2%	Explore
renal principal cell	3 studies	26% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	23% ± 5%	Explore
peripheral blood	4 studies	25% ± 4%	Explore
lung	3 studies	22% ± 4%	Explore
heart	3 studies	19% ± 3%	Explore
adipose	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2750.63	653 / 653	100%	20.98	603 / 605
intestine	100%	3312.03	966 / 966	99%	24.74	523 / 527
uterus	100%	2739.98	170 / 170	99%	22.78	455 / 459
esophagus	100%	1809.91	1445 / 1445	99%	22.71	181 / 183
ovary	100%	2876.29	180 / 180	99%	17.89	424 / 430
skin	100%	2006.19	1805 / 1809	99%	43.16	466 / 472
lung	100%	3702.94	578 / 578	98%	23.25	1136 / 1155
bladder	100%	2780.67	21 / 21	98%	24.97	494 / 504
stomach	99%	1488.18	355 / 359	99%	25.11	282 / 286
kidney	100%	2259.38	89 / 89	97%	43.02	878 / 901
adrenal gland	100%	2696.00	258 / 258	96%	20.06	220 / 230
breast	100%	1930.87	459 / 459	95%	18.95	1067 / 1118
brain	83%	1514.73	2205 / 2642	100%	28.29	705 / 705
prostate	100%	2168.84	245 / 245	80%	9.01	401 / 502
pancreas	61%	421.21	201 / 328	98%	24.01	174 / 178
liver	73%	524.31	166 / 226	38%	4.20	153 / 406
adipose	100%	2443.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2300.87	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	42.90	80 / 80
lymph node	0%	0	0 / 0	100%	94.75	29 / 29
spleen	100%	5730.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	15.66	1 / 1
heart	99%	2444.96	854 / 861	0%	0	0 / 0
peripheral blood	99%	4248.02	919 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	22.64	43 / 45
muscle	41%	348.43	330 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0032991	Cellular component	protein-containing complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0043236	Molecular function	laminin binding
GO_0030165	Molecular function	PDZ domain binding
GO_0005515	Molecular function	protein binding
GO_0008289	Molecular function	lipid binding
GO_0001968	Molecular function	fibronectin binding
GO_0043325	Molecular function	phosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]

Gene name	PLEKHA2
Protein name	Pleckstrin homology domain containing A2 Alternative protein PLEKHA2 Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)
Synonyms	TAPP2
Description	FUNCTION: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). .
Accessions	L8E8N7 ENST00000521746.5 E5RGP3 E5RHB5 A0A087WZ32 ENST00000616927.4 A0A087X038 ENST00000519640.5 ENST00000616834.1 ENST00000617275.5 Q9HB19

PLEKHA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review