PKD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	10 studies	43% ± 25%	Explore
ciliated cell	9 studies	21% ± 7%	Explore
astrocyte	9 studies	28% ± 12%	Explore
GABAergic neuron	8 studies	38% ± 24%	Explore
fibroblast	8 studies	19% ± 3%	Explore
endothelial cell	7 studies	32% ± 14%	Explore
oligodendrocyte precursor cell	6 studies	28% ± 12%	Explore
neuron	4 studies	27% ± 10%	Explore
granule cell	4 studies	33% ± 12%	Explore
retinal ganglion cell	4 studies	29% ± 9%	Explore
epithelial cell	4 studies	18% ± 3%	Explore
interneuron	4 studies	40% ± 25%	Explore
amacrine cell	3 studies	29% ± 5%	Explore
GABAergic interneuron	3 studies	19% ± 3%	Explore
myofibroblast cell	3 studies	26% ± 7%	Explore
adipocyte	3 studies	18% ± 3%	Explore
smooth muscle cell	3 studies	18% ± 2%	Explore
oligodendrocyte	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	33% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	98%	21758.53	1420 / 1445	100%	18.86	183 / 183
skin	100%	12637.65	1802 / 1809	98%	11.12	464 / 472
prostate	100%	16996.54	244 / 245	97%	9.68	487 / 502
breast	99%	11478.56	456 / 459	97%	9.25	1079 / 1118
intestine	99%	21792.11	958 / 966	97%	8.92	509 / 527
ovary	100%	17921.00	180 / 180	94%	10.11	406 / 430
brain	93%	43867.91	2464 / 2642	99%	20.92	699 / 705
uterus	99%	25476.14	169 / 170	93%	9.52	426 / 459
lung	98%	10840.80	567 / 578	94%	8.66	1087 / 1155
bladder	100%	18962.19	21 / 21	90%	6.16	453 / 504
stomach	92%	12696.81	331 / 359	97%	11.87	278 / 286
thymus	99%	8729.86	645 / 653	90%	5.28	544 / 605
adrenal gland	91%	6975.16	234 / 258	97%	29.64	223 / 230
kidney	81%	5164.96	72 / 89	96%	7.77	863 / 901
pancreas	64%	3633.45	210 / 328	97%	8.64	173 / 178
liver	47%	2493.20	107 / 226	69%	3.41	279 / 406
muscle	100%	20380.70	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.32	1 / 1
blood vessel	100%	33323.91	1334 / 1335	0%	0	0 / 0
spleen	100%	8055.36	240 / 241	0%	0	0 / 0
adipose	99%	11595.44	1196 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	9.23	79 / 80
heart	97%	11709.95	833 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	8.60	42 / 45
lymph node	0%	0	0 / 0	66%	3.78	19 / 29
peripheral blood	17%	1020.58	159 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0072164	Biological process	mesonephric tubule development
GO_0006611	Biological process	protein export from nucleus
GO_0021510	Biological process	spinal cord development
GO_0001701	Biological process	in utero embryonic development
GO_0090162	Biological process	establishment of epithelial cell polarity
GO_0048754	Biological process	branching morphogenesis of an epithelial tube
GO_0007507	Biological process	heart development
GO_0072205	Biological process	metanephric collecting duct development
GO_0001892	Biological process	embryonic placenta development
GO_0007160	Biological process	cell-matrix adhesion
GO_0072177	Biological process	mesonephric duct development
GO_0050982	Biological process	detection of mechanical stimulus
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0001822	Biological process	kidney development
GO_0034405	Biological process	response to fluid shear stress
GO_0001889	Biological process	liver development
GO_0072237	Biological process	metanephric proximal tubule development
GO_0160040	Biological process	mitocytosis
GO_0048806	Biological process	genitalia development
GO_0072218	Biological process	metanephric ascending thin limb development
GO_0072287	Biological process	metanephric distal tubule morphogenesis
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0060674	Biological process	placenta blood vessel development
GO_0051290	Biological process	protein heterotetramerization
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0048565	Biological process	digestive tract development
GO_0060428	Biological process	lung epithelium development
GO_0036303	Biological process	lymph vessel morphogenesis
GO_0060236	Biological process	regulation of mitotic spindle organization
GO_0016055	Biological process	Wnt signaling pathway
GO_0001502	Biological process	cartilage condensation
GO_0043588	Biological process	skin development
GO_0030155	Biological process	regulation of cell adhesion
GO_0021915	Biological process	neural tube development
GO_0007161	Biological process	calcium-independent cell-matrix adhesion
GO_0051216	Biological process	cartilage development
GO_0006816	Biological process	calcium ion transport
GO_0007259	Biological process	cell surface receptor signaling pathway via JAK-STAT
GO_0051726	Biological process	regulation of cell cycle
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0061136	Biological process	regulation of proteasomal protein catabolic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031514	Cellular component	motile cilium
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0060170	Cellular component	ciliary membrane
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0140494	Cellular component	migrasome
GO_0005929	Cellular component	cilium
GO_0005783	Cellular component	endoplasmic reticulum
GO_0034704	Cellular component	calcium channel complex
GO_0016328	Cellular component	lateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0002133	Cellular component	polycystin complex
GO_0030660	Cellular component	Golgi-associated vesicle membrane
GO_0034703	Cellular component	cation channel complex
GO_0005634	Cellular component	nucleus
GO_0019904	Molecular function	protein domain specific binding
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0019901	Molecular function	protein kinase binding
GO_0030246	Molecular function	carbohydrate binding
GO_0042813	Molecular function	Wnt receptor activity
GO_0005261	Molecular function	monoatomic cation channel activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0005262	Molecular function	calcium channel activity

IV. Literature review

[source]

Gene name	PKD1
Protein name	Polycystin 1, transient receptor potential channel interacting Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) PC-1 mutant (Polycystic kidney disease 1) Polycystic kidney disease-associated protein PKD1 Polysystin 1
Synonyms	pkd1
Description	FUNCTION: Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B . Both PKD1 and PKD2 are required for channel activity . Involved in renal tubulogenesis . Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria . .
Accessions	ENST00000488185.2 H3BTG3 H3BSE9 I3L4N0 H3BTE0 Q15142 ENST00000483024.1 C1JFL7 H3BV77 O75276 ENST00000568591.5 C1JFL5 ENST00000561668.5 ENST00000487932.5 ENST00000262304.9 [P98161-1] A0A097HUC6 H3BSE8 P98161 H3BQF4 C1JFL6 ENST00000423118.5 [P98161-3] A0A867GBE4 ENST00000562425.1 ENST00000567946.1

PKD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review