PIK3R3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_2000811Biological processnegative regulation of anoikis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0006955Biological processimmune response
GO_0030217Biological processT cell differentiation
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0008286Biological processinsulin receptor signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030183Biological processB cell differentiation
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene namePIK3R3
Protein namePhosphoinositide-3-kinase regulatory subunit 3
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)
PIK3R3 protein
Synonyms
DescriptionFUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

AccessionsQ8N381
ENST00000420542.5 [Q92569-1]
ENST00000262741.10 [Q92569-1]
ENST00000425892.2
Q92569
ENST00000423209.5 [Q92569-2]
Q05DQ0
ENST00000372006.5 [Q92569-1]
Q5T4P3