Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 25 studies | 37% ± 14% | |
| endothelial cell of artery | 11 studies | 43% ± 12% | |
| capillary endothelial cell | 9 studies | 24% ± 6% | |
| vein endothelial cell | 7 studies | 29% ± 8% | |
| endothelial cell of vascular tree | 5 studies | 35% ± 13% | |
| glutamatergic neuron | 4 studies | 46% ± 16% | |
| astrocyte | 4 studies | 22% ± 8% | |
| interneuron | 4 studies | 43% ± 22% | |
| GABAergic neuron | 4 studies | 45% ± 15% | |
| basal cell | 3 studies | 19% ± 4% | |
| respiratory goblet cell | 3 studies | 23% ± 5% | |
| GABAergic interneuron | 3 studies | 22% ± 4% | |
| neuron | 3 studies | 23% ± 2% | |
| oligodendrocyte precursor cell | 3 studies | 20% ± 0% | |
| GABAergic amacrine cell | 3 studies | 20% ± 1% | |
| ON-bipolar cell | 3 studies | 21% ± 4% | |
| glycinergic amacrine cell | 3 studies | 24% ± 4% | |
| Mueller cell | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 7458.06 | 459 / 459 | 100% | 60.68 | 1116 / 1118 |
| prostate | 100% | 3290.30 | 244 / 245 | 98% | 18.93 | 491 / 502 |
| brain | 96% | 3670.98 | 2534 / 2642 | 98% | 18.73 | 691 / 705 |
| adrenal gland | 100% | 2963.59 | 258 / 258 | 94% | 18.67 | 216 / 230 |
| thymus | 100% | 4056.20 | 651 / 653 | 94% | 18.96 | 570 / 605 |
| uterus | 98% | 3565.75 | 167 / 170 | 93% | 24.36 | 425 / 459 |
| kidney | 97% | 2016.97 | 86 / 89 | 87% | 23.82 | 784 / 901 |
| lung | 99% | 4979.18 | 575 / 578 | 83% | 13.42 | 953 / 1155 |
| bladder | 100% | 2918.43 | 21 / 21 | 78% | 13.64 | 395 / 504 |
| stomach | 92% | 2084.00 | 329 / 359 | 70% | 7.99 | 200 / 286 |
| intestine | 96% | 1960.55 | 924 / 966 | 64% | 6.95 | 338 / 527 |
| esophagus | 88% | 2349.16 | 1268 / 1445 | 63% | 8.75 | 116 / 183 |
| ovary | 52% | 846.69 | 94 / 180 | 88% | 19.75 | 380 / 430 |
| skin | 53% | 976.24 | 953 / 1809 | 83% | 18.28 | 392 / 472 |
| pancreas | 38% | 400.29 | 125 / 328 | 75% | 9.15 | 133 / 178 |
| adipose | 100% | 8129.28 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.89 | 1 / 1 |
| spleen | 100% | 2542.29 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 4011.87 | 855 / 861 | 0% | 0 | 0 / 0 |
| muscle | 92% | 1806.36 | 742 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 22.51 | 38 / 45 |
| blood vessel | 80% | 1743.20 | 1067 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 6.41 | 20 / 29 |
| liver | 4% | 42.46 | 9 / 226 | 24% | 2.17 | 98 / 406 |
| eye | 0% | 0 | 0 / 0 | 19% | 1.76 | 15 / 80 |
| peripheral blood | 19% | 575.17 | 173 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002042 | Biological process | cell migration involved in sprouting angiogenesis |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0046854 | Biological process | phosphatidylinositol phosphate biosynthetic process |
| GO_2000811 | Biological process | negative regulation of anoikis |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0006955 | Biological process | immune response |
| GO_0030217 | Biological process | T cell differentiation |
| GO_0036092 | Biological process | phosphatidylinositol-3-phosphate biosynthetic process |
| GO_0008286 | Biological process | insulin receptor signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0005942 | Cellular component | phosphatidylinositol 3-kinase complex |
| GO_0005943 | Cellular component | phosphatidylinositol 3-kinase complex, class IA |
| GO_0005829 | Cellular component | cytosol |
| GO_0046935 | Molecular function | 1-phosphatidylinositol-3-kinase regulator activity |
| GO_0016303 | Molecular function | 1-phosphatidylinositol-3-kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0001784 | Molecular function | phosphotyrosine residue binding |
| Gene name | PIK3R3 |
| Protein name | Phosphoinositide-3-kinase regulatory subunit 3 Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) PIK3R3 protein |
| Synonyms | |
| Description | FUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| Accessions | Q8N381 ENST00000420542.5 [Q92569-1] ENST00000262741.10 [Q92569-1] ENST00000425892.2 Q92569 ENST00000423209.5 [Q92569-2] Q05DQ0 ENST00000372006.5 [Q92569-1] Q5T4P3 |