PIK3AP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0034134Biological processtoll-like receptor 2 signaling pathway
GO_0050727Biological processregulation of inflammatory response
GO_0034154Biological processtoll-like receptor 7 signaling pathway
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0036312Molecular functionphosphatidylinositol 3-kinase regulatory subunit binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene namePIK3AP1
Protein namePhosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)
SynonymsBCAP
DescriptionFUNCTION: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. .

AccessionsENST00000339364.10 [Q6ZUJ8-1]
Q6ZUJ8
ENST00000371110.6 [Q6ZUJ8-2]
ENST00000371109.3 [Q6ZUJ8-3]