PIBF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_1905515Biological processnon-motile cilium assembly
GO_0060271Biological processcilium assembly
GO_0002376Biological processimmune system process
GO_0042976Biological processactivation of Janus kinase activity
GO_0071539Biological processprotein localization to centrosome
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0090307Biological processmitotic spindle assembly
GO_0032815Biological processnegative regulation of natural killer cell activation
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0031393Biological processnegative regulation of prostaglandin biosynthetic process
GO_0042532Biological processnegative regulation of tyrosine phosphorylation of STAT protein
GO_0005615Cellular componentextracellular space
GO_0034451Cellular componentcentriolar satellite
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005136Molecular functioninterleukin-4 receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIBF1
Protein namePIBF1 protein
Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)
Progesterone immunomodulatory binding factor 1
SynonymsPIBF
C13orf24
DescriptionFUNCTION: Plays a role in ciliogenesis. .; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity . Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation . Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 . .; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect . Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein . .

AccessionsQ4G0R1
A0A087WUI6
ENST00000617689.4
Q05DN0
ENST00000615625.1 [Q8WXW3-2]
Q8WXW3
ENST00000326291.11 [Q8WXW3-1]