PIAS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0006351Biological processDNA-templated transcription
GO_0016925Biological processprotein sumoylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003677Molecular functionDNA binding
GO_0019789Molecular functionSUMO transferase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061665Molecular functionSUMO ligase activity

IV. Literature review

[source]
Gene namePIAS2
Protein nameE3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Protein inhibitor of activated STAT 2
PIAS2 protein
Protein inhibitor of activated STAT 2 (cDNA FLJ57366, highly similar to Protein inhibitor of activated STAT2)
SynonymsPIASX
DescriptionFUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. .

AccessionsO75928
ENST00000545673.5
ENST00000592212.5
ENST00000589917.1
ENST00000586953.1
K7EMP6
ENST00000398654.7
K7EJT4
K7EQX5
A0A087WUY7
K7ER97
Q2TA77
ENST00000324794.11 [O75928-2]
A0A0A0MS92
ENST00000585916.6 [O75928-1]
ENST00000592221.5
ENST00000587810.1
B4DGW0