PCIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0032259Biological processmethylation
GO_0017148Biological processnegative regulation of translation
GO_0045727Biological processpositive regulation of translation
GO_0006417Biological processregulation of translation
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0045171Cellular componentintercellular bridge
GO_0099122Molecular functionRNA polymerase II C-terminal domain binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_1990269Molecular functionRNA polymerase II C-terminal domain phosphoserine binding
GO_0016422Molecular functionmRNA (2'-O-methyladenosine-N6-)-methyltransferase activity

IV. Literature review

[source]
Gene namePCIF1
Protein namePhosphorylated CTD interacting factor 1
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121)
SynonymsCAPAM
C20orf67
PPP1R121
DescriptionFUNCTION: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs . Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally . .

AccessionsENST00000479348.2
Q9H4Z3
ENST00000372409.8
A0A087WWZ2