Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 7 studies | 37% ± 15% | |
CD4-positive, alpha-beta T cell | 6 studies | 33% ± 15% | |
CD8-positive, alpha-beta T cell | 6 studies | 29% ± 10% | |
basal cell | 6 studies | 30% ± 14% | |
plasmablast | 5 studies | 38% ± 17% | |
progenitor cell | 5 studies | 22% ± 3% | |
endothelial cell | 5 studies | 23% ± 5% | |
erythroblast | 5 studies | 47% ± 14% | |
GABAergic neuron | 5 studies | 24% ± 7% | |
glutamatergic neuron | 5 studies | 33% ± 12% | |
hematopoietic precursor cell | 4 studies | 39% ± 10% | |
abnormal cell | 4 studies | 27% ± 7% | |
intestinal crypt stem cell | 4 studies | 26% ± 8% | |
B cell | 4 studies | 27% ± 11% | |
fibroblast | 4 studies | 28% ± 10% | |
retina horizontal cell | 4 studies | 21% ± 4% | |
dendritic cell | 4 studies | 29% ± 5% | |
natural killer cell | 4 studies | 37% ± 13% | |
regulatory T cell | 4 studies | 34% ± 18% | |
hematopoietic stem cell | 4 studies | 28% ± 13% | |
astrocyte | 4 studies | 22% ± 1% | |
conventional dendritic cell | 3 studies | 27% ± 6% | |
connective tissue cell | 3 studies | 23% ± 6% | |
T cell | 3 studies | 20% ± 1% | |
neural crest cell | 3 studies | 26% ± 3% | |
plasma cell | 3 studies | 40% ± 16% | |
ciliated cell | 3 studies | 21% ± 3% | |
granulocyte monocyte progenitor cell | 3 studies | 33% ± 8% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 50% ± 14% | |
erythrocyte | 3 studies | 49% ± 22% | |
transit amplifying cell | 3 studies | 32% ± 6% | |
neuron | 3 studies | 18% ± 1% | |
pro-B cell | 3 studies | 29% ± 11% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 24% ± 6% | |
interneuron | 3 studies | 39% ± 5% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 3094.83 | 245 / 245 | 100% | 71.70 | 502 / 502 |
esophagus | 100% | 3211.96 | 1444 / 1445 | 100% | 73.99 | 183 / 183 |
breast | 100% | 3396.29 | 459 / 459 | 100% | 91.42 | 1116 / 1118 |
brain | 100% | 3421.21 | 2637 / 2642 | 100% | 79.02 | 705 / 705 |
ovary | 100% | 3593.77 | 180 / 180 | 100% | 59.95 | 429 / 430 |
intestine | 100% | 2950.61 | 965 / 966 | 100% | 87.33 | 526 / 527 |
skin | 100% | 7569.06 | 1809 / 1809 | 100% | 100.06 | 470 / 472 |
stomach | 99% | 2035.99 | 357 / 359 | 100% | 76.20 | 286 / 286 |
bladder | 100% | 3523.33 | 21 / 21 | 99% | 74.22 | 501 / 504 |
uterus | 100% | 3332.12 | 170 / 170 | 99% | 73.69 | 456 / 459 |
liver | 100% | 4339.54 | 226 / 226 | 99% | 47.09 | 401 / 406 |
lung | 99% | 2246.16 | 570 / 578 | 100% | 71.09 | 1152 / 1155 |
adrenal gland | 100% | 5132.14 | 258 / 258 | 97% | 47.25 | 224 / 230 |
pancreas | 98% | 1939.48 | 323 / 328 | 98% | 39.98 | 175 / 178 |
thymus | 100% | 2562.07 | 653 / 653 | 97% | 33.36 | 585 / 605 |
kidney | 100% | 2916.27 | 89 / 89 | 95% | 36.54 | 856 / 901 |
adipose | 100% | 3184.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 81.17 | 29 / 29 |
spleen | 100% | 2671.39 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 67.79 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 50.08 | 1 / 1 |
muscle | 100% | 2532.51 | 801 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2419.96 | 1331 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 55.91 | 77 / 80 |
heart | 91% | 1683.16 | 783 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 58% | 5730.94 | 542 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0044208 | Biological process | 'de novo' AMP biosynthetic process |
GO_0006189 | Biological process | 'de novo' IMP biosynthetic process |
GO_0006177 | Biological process | GMP biosynthetic process |
GO_0097294 | Biological process | 'de novo' XMP biosynthetic process |
GO_0009113 | Biological process | purine nucleobase biosynthetic process |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0045296 | Molecular function | cadherin binding |
GO_0004638 | Molecular function | phosphoribosylaminoimidazole carboxylase activity |
GO_0043727 | Molecular function | 5-amino-4-imidazole carboxylate lyase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0004639 | Molecular function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | PAICS |
Protein name | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_b) |
Synonyms | PAIS ADE2 AIRC hCG_2027161 |
Description | FUNCTION: Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. . |
Accessions | ENST00000505164.5 ENST00000264221.6 [P22234-1] ENST00000399688.7 [P22234-2] P22234 ENST00000512576.3 [P22234-1] ENST00000514888.5 D6RF62 E9PBS1 |