OSBPL1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_0016192Biological processvesicle-mediated transport
GO_0006699Biological processbile acid biosynthetic process
GO_0006869Biological processlipid transport
GO_0070062Cellular componentextracellular exosome
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0005770Cellular componentlate endosome
GO_0005886Cellular componentplasma membrane
GO_0044232Cellular componentorganelle membrane contact site
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene nameOSBPL1A
Protein nameOxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)
Oxysterol binding protein like 1A
Oxysterol-binding protein
SynonymsOSBP8
OSBPL1
ORP1
OSBPL1B
hCG_2020467
DescriptionFUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A . Binds 25-hydroxycholesterol and cholesterol . .

AccessionsENST00000399441.4
ENST00000579851.5
Q6DKJ0
ENST00000584119.1
ENST00000319481.8 [Q9BXW6-1]
ENST00000399443.7 [Q9BXW6-2]
B0YJ56
Q9BXW6
ENST00000582645.5
J3KSG6
J3KTA6
J3QSB8
B7ZLX8
ENST00000578091.5
E7ER58
ENST00000578055.5
ENST00000357041.8 [Q9BXW6-4]
J3KRT6
J3QLA2
ENST00000578013.1
J3QS61
Q6GSK5