OAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045071Biological processnegative regulation of viral genome replication
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0071659Biological processnegative regulation of IP-10 production
GO_0035458Biological processcellular response to interferon-beta
GO_0098586Biological processcellular response to virus
GO_0060700Biological processregulation of ribonuclease activity
GO_0043129Biological processsurfactant homeostasis
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0006006Biological processglucose metabolic process
GO_0070106Biological processinterleukin-27-mediated signaling pathway
GO_0042593Biological processglucose homeostasis
GO_2000342Biological processnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO_0140374Biological processantiviral innate immune response
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0001730Molecular function2'-5'-oligoadenylate synthetase activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameOAS1
Protein name2'-5'-oligoadenylate synthetase 1
2'-5' oligoadenylate synthetase 1 p41 isoform
2'-5' oligoadenylate synthase (EC 2.7.7.84)
2'-5' oligoadenylate synthetase 1 p49 isoform
2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS)
Truncated 2'-5' oligoadenylate synthetase
SynonymsOIAS
DescriptionFUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response . In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication . Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. .; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target . The same mechanism is necessary to initiate a block to cardiovirus EMCV . .; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. .

AccessionsENST00000679841.1
ENST00000550883.2
ENST00000680934.1
ENST00000679767.1
S4R467
ENST00000675868.2
ENST00000452357.7 [P00973-2]
H0YIB8
A0A7P0T8F9
ENST00000680522.1
ENST00000679987.1
ENST00000679467.1
A0A7P0T960
ENST00000680189.1 [P00973-1]
ENST00000202917.10 [P00973-1]
ENST00000540589.3
A0A7P0T9Q4
ENST00000679494.1
ENST00000680455.1
ENST00000552526.2
F8VPW7
ENST00000553185.2
C6EMZ7
B4DWE7
Q1P9K4
A0A7P0T879
A0A7P0TBG0
A7YIG8
ENST00000550689.2
A0A7P0Z4N8
ENST00000553152.2
ENST00000681700.1
A0A7P0T8E1
A0A7P0T854
ENST00000681934.1 [P00973-1]
A0A7P0Z4B6
F8VUC8
ENST00000680659.1
A0A7P0TAY6
A0A7P0Z444
ENST00000680919.1
ENST00000681505.1
A0A7P0T9J4
A0A7P0TB35
S4R3A5
P00973
ENST00000679971.1
ENST00000551241.6 [P00973-4]
Q3ZM02
A0A6Q8PHR1
ENST00000681228.1
ENST00000445409.7 [P00973-3]