NXN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0016055Biological processWnt signaling pathway
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0072359Biological processcirculatory system development
GO_0030154Biological processcell differentiation
GO_0098869Biological processcellular oxidant detoxification
GO_0001701Biological processin utero embryonic development
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004791Molecular functionthioredoxin-disulfide reductase (NADPH) activity

IV. Literature review

[source]
Gene nameNXN
Protein nameNucleoredoxin (EC 1.8.1.8)
Nucleoredoxin
SynonymsNRX
DescriptionFUNCTION: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). .

AccessionsENST00000575801.5 [Q6DKJ4-3]
ENST00000336868.8 [Q6DKJ4-1]
ENST00000628478.1
A0A0G2JQK5
ENST00000627182.1
ENST00000537628.6
ENST00000571684.5
A0A0C4DGI2
Q6DKJ4
I3L4V6