Name | Number of supported studies | Average coverage | |
---|---|---|---|
smooth muscle cell | 25 studies | 34% ± 15% | |
fibroblast | 22 studies | 27% ± 10% | |
pericyte | 22 studies | 37% ± 15% | |
endothelial cell | 20 studies | 24% ± 9% | |
endothelial cell of lymphatic vessel | 17 studies | 33% ± 12% | |
ciliated cell | 14 studies | 29% ± 12% | |
B cell | 12 studies | 24% ± 4% | |
epithelial cell | 12 studies | 31% ± 15% | |
erythrocyte | 9 studies | 42% ± 13% | |
connective tissue cell | 8 studies | 28% ± 9% | |
T cell | 7 studies | 20% ± 5% | |
plasma cell | 7 studies | 21% ± 8% | |
kidney loop of Henle epithelial cell | 7 studies | 48% ± 17% | |
abnormal cell | 7 studies | 23% ± 8% | |
endothelial cell of artery | 7 studies | 31% ± 21% | |
glutamatergic neuron | 7 studies | 27% ± 14% | |
astrocyte | 6 studies | 37% ± 16% | |
basal cell | 6 studies | 24% ± 8% | |
memory B cell | 6 studies | 20% ± 8% | |
natural killer cell | 5 studies | 19% ± 4% | |
retinal ganglion cell | 5 studies | 42% ± 26% | |
myofibroblast cell | 5 studies | 25% ± 14% | |
cardiac muscle cell | 5 studies | 47% ± 11% | |
Mueller cell | 5 studies | 49% ± 17% | |
regulatory T cell | 5 studies | 18% ± 4% | |
macrophage | 4 studies | 21% ± 5% | |
secretory cell | 4 studies | 20% ± 3% | |
CD4-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
conventional dendritic cell | 4 studies | 25% ± 5% | |
kidney distal convoluted tubule epithelial cell | 4 studies | 53% ± 20% | |
lymphocyte | 4 studies | 24% ± 6% | |
adipocyte | 4 studies | 25% ± 8% | |
luminal cell of prostate epithelium | 4 studies | 24% ± 6% | |
enteroendocrine cell | 4 studies | 32% ± 10% | |
gamma-delta T cell | 4 studies | 29% ± 11% | |
endothelial cell of vascular tree | 4 studies | 35% ± 24% | |
plasmablast | 3 studies | 35% ± 13% | |
erythroblast | 3 studies | 40% ± 25% | |
placental villous trophoblast | 3 studies | 29% ± 10% | |
myeloid cell | 3 studies | 21% ± 3% | |
Schwann cell | 3 studies | 48% ± 17% | |
neuron | 3 studies | 23% ± 7% | |
muscle cell | 3 studies | 48% ± 20% | |
CD8-positive, alpha-beta T cell | 3 studies | 19% ± 5% | |
goblet cell | 3 studies | 23% ± 2% | |
intestinal crypt stem cell | 3 studies | 18% ± 2% | |
glial cell | 3 studies | 33% ± 22% | |
group 3 innate lymphoid cell | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 5072.25 | 245 / 245 | 100% | 49.76 | 502 / 502 |
intestine | 100% | 2840.21 | 966 / 966 | 99% | 26.36 | 523 / 527 |
breast | 100% | 3084.97 | 459 / 459 | 99% | 18.68 | 1107 / 1118 |
thymus | 100% | 3736.12 | 652 / 653 | 99% | 17.34 | 599 / 605 |
bladder | 100% | 3267.76 | 21 / 21 | 99% | 22.22 | 498 / 504 |
esophagus | 99% | 3725.20 | 1427 / 1445 | 100% | 17.99 | 183 / 183 |
pancreas | 98% | 1852.93 | 323 / 328 | 99% | 18.98 | 177 / 178 |
lung | 99% | 2549.40 | 573 / 578 | 98% | 12.99 | 1137 / 1155 |
stomach | 98% | 2251.90 | 353 / 359 | 99% | 28.82 | 283 / 286 |
uterus | 100% | 2432.62 | 170 / 170 | 95% | 11.75 | 438 / 459 |
adrenal gland | 100% | 6068.53 | 258 / 258 | 94% | 13.24 | 216 / 230 |
ovary | 100% | 8094.55 | 180 / 180 | 93% | 12.46 | 400 / 430 |
kidney | 100% | 4116.33 | 89 / 89 | 93% | 13.81 | 838 / 901 |
skin | 97% | 1949.80 | 1761 / 1809 | 92% | 15.72 | 433 / 472 |
brain | 89% | 1898.12 | 2352 / 2642 | 100% | 29.83 | 705 / 705 |
liver | 91% | 1114.94 | 206 / 226 | 79% | 6.78 | 319 / 406 |
adipose | 100% | 3435.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6191.56 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1586.13 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.05 | 1 / 1 |
muscle | 100% | 3820.14 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 7356.36 | 841 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 7.94 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 86% | 11.19 | 25 / 29 |
peripheral blood | 79% | 2412.41 | 732 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 6.36 | 54 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1901909 | Biological process | diadenosine hexaphosphate catabolic process |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0035556 | Biological process | intracellular signal transduction |
GO_1901911 | Biological process | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
GO_0071543 | Biological process | diphosphoinositol polyphosphate metabolic process |
GO_1901907 | Biological process | diadenosine pentaphosphate catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0052848 | Molecular function | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
GO_0034431 | Molecular function | bis(5'-adenosyl)-hexaphosphatase activity |
GO_0034432 | Molecular function | bis(5'-adenosyl)-pentaphosphatase activity |
GO_0140933 | Molecular function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
GO_0008486 | Molecular function | diphosphoinositol-polyphosphate diphosphatase activity |
GO_0030515 | Molecular function | snoRNA binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0052845 | Molecular function | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
GO_0000298 | Molecular function | endopolyphosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NUDT4 |
Protein name | Nudix hydrolase 4 Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4) |
Synonyms | HDCMB47P DIPP2 KIAA0487 |
Description | FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). . |
Accessions | F8VRR0 F8VRL4 A0A0C4DGJ4 ENST00000337179.9 [Q9NZJ9-2] ENST00000546925.1 ENST00000415493.7 [Q9NZJ9-1] ENST00000547014.5 [Q9NZJ9-3] ENST00000548662.5 Q9NZJ9 ENST00000549992.5 ENST00000550056.5 |