NUDT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901909Biological processdiadenosine hexaphosphate catabolic process
GO_0019722Biological processcalcium-mediated signaling
GO_0035556Biological processintracellular signal transduction
GO_1901911Biological processadenosine 5'-(hexahydrogen pentaphosphate) catabolic process
GO_0071543Biological processdiphosphoinositol polyphosphate metabolic process
GO_1901907Biological processdiadenosine pentaphosphate catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0052848Molecular functioninositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO_0034431Molecular functionbis(5'-adenosyl)-hexaphosphatase activity
GO_0034432Molecular functionbis(5'-adenosyl)-pentaphosphatase activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0008486Molecular functiondiphosphoinositol-polyphosphate diphosphatase activity
GO_0030515Molecular functionsnoRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0052845Molecular functioninositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO_0000298Molecular functionendopolyphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUDT4
Protein nameNudix hydrolase 4
Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4)
SynonymsHDCMB47P
DIPP2
KIAA0487
DescriptionFUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). .

AccessionsF8VRR0
F8VRL4
A0A0C4DGJ4
ENST00000337179.9 [Q9NZJ9-2]
ENST00000546925.1
ENST00000415493.7 [Q9NZJ9-1]
ENST00000547014.5 [Q9NZJ9-3]
ENST00000548662.5
Q9NZJ9
ENST00000549992.5
ENST00000550056.5