NUDT16L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0006402Biological processmRNA catabolic process
GO_0016077Biological processsno(s)RNA catabolic process
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0030515Molecular functionsnoRNA binding
GO_1990174Molecular functionphosphodiesterase decapping endonuclease activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNUDT16L1
Protein nameNudix hydrolase 16 like 1
Nudix (Nucleoside diphosphate linked moiety X)-type motif 16-like 1, isoform CRA_b (Nudix hydrolase 16 like 1)
Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)
Alternative protein NUDT16L1
SynonymshCG_15176
SDOS
TIRR
DescriptionFUNCTION: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin . In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus . Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) . Binds U8 snoRNA . .

AccessionsK7ENA3
ENST00000405142.1 [Q9BRJ7-2]
L8EAI7
ENST00000586536.1
W4VSQ8
ENST00000590460.1
ENST00000304301.11 [Q9BRJ7-1]
ENST00000586252.1
K7EIN2
Q9BRJ7